DegronMD

Uniprot ID: O43157

Source protein: Plexin-B1

Source gene: PLXNB1

Class: DEG_APCC_DBOX_1

Location: 76:84

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9971

ASA_SCORE: 70.6222

COIL: 0.8557

CONS_SCORE: 0.5355

DSS_SCORE: 0.4692

HELIX: 0.0709

FCONS_SCORE: 1.232

RIG_SCORE: 0.7263

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P81S	TCGA-BG-A0LX	UCEC	TCGA	SRDCLPPVM	DEG_APCC_DBOX_1	0.5641
p.P81S	DO41919	UCEC	ICGC	SRDCLPPVM	DEG_APCC_DBOX_1	0.5641
p.R80C	DO7828	COAD	ICGC	SRDCLPPVM	DEG_APCC_DBOX_1	0.8301
p.L83M	DO228948	LICA	ICGC	SRDCLPPVM	DEG_APCC_DBOX_1	0.711
p.T67K	DO228986	LICA	ICGC	SRDCLPPVM	DEG_APCC_DBOX_1	0.0833
p.F81L	DO229029	LICA	ICGC	SRDCLPPVM	DEG_APCC_DBOX_1	0.6981
p.S76R	DO229035	LICA	ICGC	SRDCLPPVM	DEG_APCC_DBOX_1	0.6316
p.S76R	ACH-000964	Leukemia	CCLE	SRDCLPPVM	DEG_APCC_DBOX_1	0.6316
p.S82F	DO220911	MELA	ICGC	SRDCLPPVM	DEG_APCC_DBOX_1	0.7982
p.L79S	DO47867	STAD	ICGC	SRDCLPPVM	DEG_APCC_DBOX_1	0.7667
p.P93H	DO42673	UCEC	ICGC	SRDCLPPVM	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43157	Plexin-B1	DEG_APCC_DBOX_1	76:84	SRDCLPPVM	APC,CDC20,FZR1	0.9971	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons