DegronMD

Uniprot ID: O43157

Source protein: Plexin-B1

Source gene: PLXNB1

Class: DEG_SPOP_SBC_1

Location: 862:866

E3 ligase: SPOP

DEGRON score: 0.9864

ASA_SCORE: 45.02

COIL: 0.7406

CONS_SCORE: 0.3883

DSS_SCORE: 0.6156

HELIX: 0.087

FCONS_SCORE: 1.0743

RIG_SCORE: 0.7151

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S870L	TCGA-78-7161	LUAD	TCGA	AFSTS	DEG_SPOP_SBC_1	0.2222
p.A860T	TCGA-BR-8487	STAD	TCGA	AFSTS	DEG_SPOP_SBC_1	0.2778
p.A860T	TCGA-NH-A5IV	COAD	TCGA	AFSTS	DEG_SPOP_SBC_1	0.2778
p.A860T	DO49095	COAD	ICGC	AFSTS	DEG_SPOP_SBC_1	0.2778
p.A860T	DO47867	STAD	ICGC	AFSTS	DEG_SPOP_SBC_1	0.2778
p.A860T	SIDM02049	Pancreatic Carcinoma	GDSC	AFSTS	DEG_SPOP_SBC_1	0.2778
p.D853Y	TCGA-D9-A1JW	SKCM	TCGA	AFSTS	DEG_SPOP_SBC_1	0.0833
p.D853Y	DO37786	SKCM	ICGC	AFSTS	DEG_SPOP_SBC_1	0.0833
p.S864F	DO8658	COAD	ICGC	AFSTS	DEG_SPOP_SBC_1	0.7982
p.P854S	DO8463	COAD	ICGC	AFSTS	DEG_SPOP_SBC_1	0.1111
p.S866Y	DO224628	COCA	ICGC	AFSTS	DEG_SPOP_SBC_1	0.712
p.E872K	DO22237	LGG	ICGC	AFSTS	DEG_SPOP_SBC_1	0.1667
p.T867N	DO229036	LICA	ICGC	AFSTS	DEG_SPOP_SBC_1	0.3056
p.R867C	DO27596	LUSC	ICGC	AFSTS	DEG_SPOP_SBC_1	0.3056
p.P866S	DO35128	PACA	ICGC	AFSTS	DEG_SPOP_SBC_1	0.6752
p.G863W	DO37971	SKCM	ICGC	AFSTS	DEG_SPOP_SBC_1	0.7825
p.R865H	DO38727	STAD	ICGC	AFSTS	DEG_SPOP_SBC_1	0.8244
p.R871W	DO42312	UCEC	ICGC	AFSTS	DEG_SPOP_SBC_1	0.1944
p.A862V	DO42673	UCEC	ICGC	AFSTS	DEG_SPOP_SBC_1	0.5825
p.D874H	SIDM00920	Breast Carcinoma	GDSC	AFSTS	DEG_SPOP_SBC_1	0.1111
p.D874H	ACH-000783	Breast Cancer	CCLE	AFSTS	DEG_SPOP_SBC_1	0.1111
p.D874H	CAMA-1	breast	COSMIC	AFSTS	DEG_SPOP_SBC_1	0.1111
p.T856M	ACH-001786	Colon/Colorectal Cancer	CCLE	AFSTS	DEG_SPOP_SBC_1	0.1667
p.R865C	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	AFSTS	DEG_SPOP_SBC_1	0.8301

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43157	Plexin-B1	DEG_SPOP_SBC_1	862:866	AFSTS	SPOP	0.9864	More...
Q6VMQ6	Activating transcription factor 7-interacting protein 1	DEG_SPOP_SBC_1	915:919	AFSTS	SPOP	0.9877	More...
Q6ZSB9	Zinc finger and BTB domain-containing protein 49	DEG_SPOP_SBC_1	242:246	AFSTS	SPOP	0.9947	More...
Q96J92	Serine/threonine-protein kinase WNK4	DEG_SPOP_SBC_1	799:803	AFSTS	SPOP	0.6668	More...
Q9H4B6	Protein salvador homolog 1	DEG_SPOP_SBC_1	59:63	AFSTS	SPOP	0.9968	More...
Q9Y4K1	Beta/gamma crystallin domain-containing protein 1	DEG_SPOP_SBC_1	861:865	AFSTS	SPOP	0.9833	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons