DegronMD - Q6ZSB9(ZBTB49)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G724C	TCGA-97-7941	LUAD	TCGA	ASSTT	DEG_SPOP_SBC_1	731:735	Mutation rewiring degron network	0.1389
p.G723V	TCGA-DX-A6YV	SARC	TCGA	ASSTT	DEG_SPOP_SBC_1	731:735	Mutation rewiring degron network	0.1111
p.D725N	TCGA-FD-A3SO	BLCA	TCGA	ASSTT	DEG_SPOP_SBC_1	731:735	Mutation rewiring degron network	0.1667
p.S732F	TCGA-FD-A6TC	BLCA	TCGA	ASSTT	DEG_SPOP_SBC_1	731:735	Mutation altering degron motif	0.6871
p.V252L	TCGA-ZH-A8Y4	CHOL	TCGA	AFSTS	DEG_SPOP_SBC_1	242:246	Mutation rewiring degron network	0.1667
p.D247H	DO4221	BRCA	ICGC	AFSTS	DEG_SPOP_SBC_1	242:246	Mutation rewiring degron network	0.3056
p.S149I	DO228974	LICA	ICGC	LTPDAT	DEG_SCF_FBW7_1	140:145	Mutation rewiring degron network	0.2222
p.Q239H	DO229019	LICA	ICGC	AFSTS	DEG_SPOP_SBC_1	242:246	Mutation rewiring degron network	0.25
p.S148I	DO229031	LICA	ICGC	LTPDAT	DEG_SCF_FBW7_1	140:145	Mutation rewiring degron network	0.25
p.M141V	DO44786	LICA	ICGC	LTPDAT	DEG_SCF_FBW7_1	140:145	Mutation altering degron motif	0.7208
p.R139L	DO50279	SKCM	ICGC	LTPDAT	DEG_SCF_FBW7_1	140:145	Mutation rewiring degron network	0.3056
p.P144H	DO41361	UCEC	ICGC	LTPDAT	DEG_SCF_FBW7_1	140:145	Mutation altering degron motif	0.7694
p.P726S	SIDM01175	Other Sarcomas	GDSC	ASSTT	DEG_SPOP_SBC_1	731:735	Mutation rewiring degron network	0.1944
p.P726S	SIDM00150	Colorectal Carcinoma	GDSC	ASSTT	DEG_SPOP_SBC_1	731:735	Mutation rewiring degron network	0.1944
p.P726S	ACH-000969	Colon/Colorectal Cancer	CCLE	ASSTT	DEG_SPOP_SBC_1	731:735	Mutation rewiring degron network	0.1944
p.P726S	ACH-002309	Sarcoma	CCLE	ASSTT	DEG_SPOP_SBC_1	731:735	Mutation rewiring degron network	0.1944
p.P726S	KM12	large intestine	COSMIC	ASSTT	DEG_SPOP_SBC_1	731:735	Mutation rewiring degron network	0.1944
p.P726S	SW684	soft tissue	COSMIC	ASSTT	DEG_SPOP_SBC_1	731:735	Mutation rewiring degron network	0.1944
p.D248N	SIDM00516	Melanoma	GDSC	AFSTS	DEG_SPOP_SBC_1	242:246	Mutation rewiring degron network	0.2778
p.D248N	ACH-002166	Skin Cancer	CCLE	AFSTS	DEG_SPOP_SBC_1	242:246	Mutation rewiring degron network	0.2778
p.D248N	MZ7-mel	skin	COSMIC	AFSTS	DEG_SPOP_SBC_1	242:246	Mutation rewiring degron network	0.2778
p.T251M	ACH-000460	Ovarian Cancer	CCLE	AFSTS	DEG_SPOP_SBC_1	242:246	Mutation rewiring degron network	0.1944
p.P142L	ACH-000923	Lymphoma	CCLE	LTPDAT	DEG_SCF_FBW7_1	140:145	Mutation altering degron motif	0.7582

Kaplan plot for ZBTB49 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZBTB49

UniProt ID: Q6ZSB9

Entrez ID: 166793

Protein name: Zinc finger and BTB domain-containing protein 49 (Zinc finger protein 509)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZBTB49 in