DegronMD

Uniprot ID: Q6ZSB9

Source protein: Zinc finger and BTB domain-containing protein 49

Source gene: ZBTB49

Class: DEG_SCF_FBW7_1

Location: 140:145

E3 ligase: FBXW7

DEGRON score: 0.9781

ASA_SCORE: 65.8

COIL: 0.84

CONS_SCORE: 0.4929

DSS_SCORE: 0.2973

HELIX: 0.0777

FCONS_SCORE: 0.8273

RIG_SCORE: 0.7666

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S149I	DO228974	LICA	ICGC	LTPDAT	DEG_SCF_FBW7_1	0.2222
p.S148I	DO229031	LICA	ICGC	LTPDAT	DEG_SCF_FBW7_1	0.25
p.M141V	DO44786	LICA	ICGC	LTPDAT	DEG_SCF_FBW7_1	0.7208
p.R139L	DO50279	SKCM	ICGC	LTPDAT	DEG_SCF_FBW7_1	0.3056
p.P144H	DO41361	UCEC	ICGC	LTPDAT	DEG_SCF_FBW7_1	0.7694
p.P142L	ACH-000923	Lymphoma	CCLE	LTPDAT	DEG_SCF_FBW7_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZSB9	Zinc finger and BTB domain-containing protein 49	DEG_SCF_FBW7_1	140:145	LTPDAT	FBXW7	0.9781	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons