DegronMD

Uniprot ID: Q6ZSB9

Source protein: Zinc finger and BTB domain-containing protein 49

Source gene: ZBTB49

Class: DEG_SPOP_SBC_1

Location: 242:246

E3 ligase: SPOP

DEGRON score: 0.9947

ASA_SCORE: 69.52

COIL: 0.752

CONS_SCORE: 0.4521

DSS_SCORE: 0.4004

HELIX: 0.055

FCONS_SCORE: 0.8398

RIG_SCORE: 0.7372

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V252L	TCGA-ZH-A8Y4	CHOL	TCGA	AFSTS	DEG_SPOP_SBC_1	0.1667
p.D247H	DO4221	BRCA	ICGC	AFSTS	DEG_SPOP_SBC_1	0.3056
p.Q239H	DO229019	LICA	ICGC	AFSTS	DEG_SPOP_SBC_1	0.25
p.D248N	SIDM00516	Melanoma	GDSC	AFSTS	DEG_SPOP_SBC_1	0.2778
p.D248N	ACH-002166	Skin Cancer	CCLE	AFSTS	DEG_SPOP_SBC_1	0.2778
p.D248N	MZ7-mel	skin	COSMIC	AFSTS	DEG_SPOP_SBC_1	0.2778
p.T251M	ACH-000460	Ovarian Cancer	CCLE	AFSTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43157	Plexin-B1	DEG_SPOP_SBC_1	862:866	AFSTS	SPOP	0.9864	More...
Q6VMQ6	Activating transcription factor 7-interacting protein 1	DEG_SPOP_SBC_1	915:919	AFSTS	SPOP	0.9877	More...
Q6ZSB9	Zinc finger and BTB domain-containing protein 49	DEG_SPOP_SBC_1	242:246	AFSTS	SPOP	0.9947	More...
Q96J92	Serine/threonine-protein kinase WNK4	DEG_SPOP_SBC_1	799:803	AFSTS	SPOP	0.6668	More...
Q9H4B6	Protein salvador homolog 1	DEG_SPOP_SBC_1	59:63	AFSTS	SPOP	0.9968	More...
Q9Y4K1	Beta/gamma crystallin domain-containing protein 1	DEG_SPOP_SBC_1	861:865	AFSTS	SPOP	0.9833	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons