DegronMD

Uniprot ID: Q9Y4K1

Source protein: Beta/gamma crystallin domain-containing protein 1

Source gene: CRYBG1

Class: DEG_SPOP_SBC_1

Location: 861:865

E3 ligase: SPOP

DEGRON score: 0.9833

ASA_SCORE: 80.88

COIL: 0.8452

CONS_SCORE: 0.6303

DSS_SCORE: 0.4604

HELIX: 0.1072

FCONS_SCORE: 0.9385

RIG_SCORE: 0.7276

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A861V	NCI-H1876	lung	COSMIC	AFSTS	DEG_SPOP_SBC_1	0.5825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43157	Plexin-B1	DEG_SPOP_SBC_1	862:866	AFSTS	SPOP	0.9864	More...
Q6VMQ6	Activating transcription factor 7-interacting protein 1	DEG_SPOP_SBC_1	915:919	AFSTS	SPOP	0.9877	More...
Q6ZSB9	Zinc finger and BTB domain-containing protein 49	DEG_SPOP_SBC_1	242:246	AFSTS	SPOP	0.9947	More...
Q96J92	Serine/threonine-protein kinase WNK4	DEG_SPOP_SBC_1	799:803	AFSTS	SPOP	0.6668	More...
Q9H4B6	Protein salvador homolog 1	DEG_SPOP_SBC_1	59:63	AFSTS	SPOP	0.9968	More...
Q9Y4K1	Beta/gamma crystallin domain-containing protein 1	DEG_SPOP_SBC_1	861:865	AFSTS	SPOP	0.9833	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons