DegronMD

Uniprot ID: Q96J92

Source protein: Serine/threonine-protein kinase WNK4

Source gene: WNK4

Class: DEG_COP1_1

Location: 136:145

E3 ligase: COP1

DEGRON score: 0.9935

ASA_SCORE: 99.61

COIL: 0.7127

CONS_SCORE: 0.423

DSS_SCORE: 0.6384

HELIX: 0.256

FCONS_SCORE: 1.3282

RIG_SCORE: 0.6609

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G133D	TCGA-17-Z031	LUAD	TCGA	SREPLRVPEA	DEG_COP1_1	0.25
p.A147V	TCGA-EO-A3AZ	UCEC	TCGA	SREPLRVPEA	DEG_COP1_1	0.2778
p.A147V	DO50078	UCEC	ICGC	SREPLRVPEA	DEG_COP1_1	0.2778
p.E155K	TCGA-GF-A6C9	SKCM	TCGA	SREPLRVPEA	DEG_COP1_1	0.0556
p.E155K	DO51254	SKCM	ICGC	SREPLRVPEA	DEG_COP1_1	0.0556
p.R152W	DO230323	COCA	ICGC	SREPLRVPEA	DEG_COP1_1	0.1389
p.S136P	DO232224	PBCA	ICGC	SREPLRVPEA	DEG_COP1_1	0.6752
p.E153G	DO219881	SKCA	ICGC	SREPLRVPEA	DEG_COP1_1	0.1111
p.E153G	ACH-000615	Skin Cancer	CCLE	SREPLRVPEA	DEG_COP1_1	0.1111
p.P128L	SIDM00267	Biliary Tract Carcinoma	GDSC	SREPLRVPEA	DEG_COP1_1	0.1111
p.P128L	SIDM01464	Pancreatic Carcinoma	GDSC	SREPLRVPEA	DEG_COP1_1	0.1111
p.P128L	ACH-000498	Leukemia	CCLE	SREPLRVPEA	DEG_COP1_1	0.1111
p.P128L	ACH-000502	Pancreatic Cancer	CCLE	SREPLRVPEA	DEG_COP1_1	0.1111
p.P128L	ACH-002312	Gallbladder Cancer	CCLE	SREPLRVPEA	DEG_COP1_1	0.1111
p.P128L	TGBC24TKB	biliary_tract	COSMIC	SREPLRVPEA	DEG_COP1_1	0.1111
p.Q154R	ACH-002027	Endometrial/Uterine Cancer	CCLE	SREPLRVPEA	DEG_COP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96J92	Serine/threonine-protein kinase WNK4	DEG_COP1_1	136:145	SREPLRVPEA	COP1	0.9935	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons