DegronMD

Uniprot ID: Q96J92

Source protein: Serine/threonine-protein kinase WNK4

Source gene: WNK4

Class: DEG_SCF_FBW7_1

Location: 1044:1050

E3 ligase: FBXW7

DEGRON score: 0.9342

ASA_SCORE: 90.9714

COIL: 0.942

CONS_SCORE: 0.4834

DSS_SCORE: 0.8434

HELIX: 0.0227

FCONS_SCORE: 1.064

RIG_SCORE: 0.5331

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1039C	TCGA-23-1027	OV	TCGA	PSTPQLT	DEG_SCF_FBW7_1	0.1944
p.S1039C	DO30540	OV	ICGC	PSTPQLT	DEG_SCF_FBW7_1	0.1944
p.E1052K	TCGA-CN-4723	HNSC	TCGA	PSTPQLT	DEG_SCF_FBW7_1	0.2778
p.E1052K	DO14830	HNSC	ICGC	PSTPQLT	DEG_SCF_FBW7_1	0.2778
p.P1044H	DO228345	BRCA	ICGC	PSTPQLT	DEG_SCF_FBW7_1	0.7694
p.S1045L	DO222391	BTCA	ICGC	PSTPQLT	DEG_SCF_FBW7_1	0.6556
p.P1047H	DO222755	COCA	ICGC	PSTPQLT	DEG_SCF_FBW7_1	0.7694
p.S1045P	DO223068	ESCA	ICGC	PSTPQLT	DEG_SCF_FBW7_1	0.5641
p.G1040C	DO229031	LICA	ICGC	PSTPQLT	DEG_SCF_FBW7_1	0.2222
p.E1057A	ACH-001042	Ovarian Cancer	CCLE	PSTPQLT	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96J92	Serine/threonine-protein kinase WNK4	DEG_SCF_FBW7_1	1044:1050	PSTPQLT	FBXW7	0.9342	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons