DegronMD

Uniprot ID: Q96J92

Source protein: Serine/threonine-protein kinase WNK4

Source gene: WNK4

Class: DEG_Kelch_KLHL3_1

Location: 557:566

E3 ligase: CUL3,KLHL3,KLHL2

DEGRON score: 0.9797

ASA_SCORE: 100.75

COIL: 0.8102

CONS_SCORE: 0.4406

DSS_SCORE: 0.7691

HELIX: 0.1575

FCONS_SCORE: 1.0059

RIG_SCORE: 0.6185

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A574G	TCGA-49-4487	LUAD	TCGA	EPEEPEADQH	DEG_Kelch_KLHL3_1	0.1111
p.A574G	DO24780	LUAD	ICGC	EPEEPEADQH	DEG_Kelch_KLHL3_1	0.1111
p.A547V	TCGA-94-8491	LUSC	TCGA	EPEEPEADQH	DEG_Kelch_KLHL3_1	0.0556
p.A547V	DO219174	LUSC	ICGC	EPEEPEADQH	DEG_Kelch_KLHL3_1	0.0556
p.E559K	TCGA-A8-A08H	BRCA	TCGA	EPEEPEADQH	DEG_Kelch_KLHL3_1	0.7022
p.E559K	DO5563	BRCA	ICGC	EPEEPEADQH	DEG_Kelch_KLHL3_1	0.7022
p.L570F	TCGA-FW-A5DY	SKCM	TCGA	EPEEPEADQH	DEG_Kelch_KLHL3_1	0.2222
p.L570F	DO47257	SKCM	ICGC	EPEEPEADQH	DEG_Kelch_KLHL3_1	0.2222
p.G549V	DO44111	BRCA	ICGC	EPEEPEADQH	DEG_Kelch_KLHL3_1	0.1111
p.P551L	DO220891	MELA	ICGC	EPEEPEADQH	DEG_Kelch_KLHL3_1	0.1667
p.S552R	DO227850	PBCA	ICGC	EPEEPEADQH	DEG_Kelch_KLHL3_1	0.1944
p.P551T	SIDM00151	Ovarian Carcinoma	GDSC	EPEEPEADQH	DEG_Kelch_KLHL3_1	0.1667
p.P551T	ACH-000966	Ovarian Cancer	CCLE	EPEEPEADQH	DEG_Kelch_KLHL3_1	0.1667
p.P551T	IGROV-1	ovary	COSMIC	EPEEPEADQH	DEG_Kelch_KLHL3_1	0.1667
p.P555R	SIDM00032	Bladder Carcinoma	GDSC	EPEEPEADQH	DEG_Kelch_KLHL3_1	0.2778
p.P555R	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	EPEEPEADQH	DEG_Kelch_KLHL3_1	0.2778
p.P555R	SIDM00785	Acute Myeloid Leukemia	GDSC	EPEEPEADQH	DEG_Kelch_KLHL3_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96J92	Serine/threonine-protein kinase WNK4	DEG_Kelch_KLHL3_1	557:566	EPEEPEADQH	CUL3,KLHL3,KLHL2	0.9797	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_Kelch_KLHL3_1	628:637	EPEEPEADQH	CUL3,KLHL3,KLHL2	0.9925	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_Kelch_KLHL3_1	588:597	EPEEPEADQH	CUL3,KLHL3,KLHL2	0.9853	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons