DegronMD

Uniprot ID: Q9H4A3

Source protein: Serine/threonine-protein kinase WNK1

Source gene: WNK1

Class: DEG_Kelch_KLHL3_1

Location: 628:637

E3 ligase: CUL3,KLHL3,KLHL2

DEGRON score: 0.9925

ASA_SCORE: 100.27

COIL: 0.6835

CONS_SCORE: 0.4

DSS_SCORE: 0.7687

HELIX: 0.29

FCONS_SCORE: 1.1555

RIG_SCORE: 0.6815

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D635V	TCGA-DI-A1BU	UCEC	TCGA	EPEEPEADQH	DEG_Kelch_KLHL3_1	0.7785
p.D635V	DO42023	UCEC	ICGC	EPEEPEADQH	DEG_Kelch_KLHL3_1	0.7785
p.E642Q	DO49760	BLCA	ICGC	EPEEPEADQH	DEG_Kelch_KLHL3_1	0.1944
p.Q637H	DO228952	LICA	ICGC	EPEEPEADQH	DEG_Kelch_KLHL3_1	0.7582
p.A639S	DO229019	LICA	ICGC	EPEEPEADQH	DEG_Kelch_KLHL3_1	0.2778
p.A641S	DO229019	LICA	ICGC	EPEEPEADQH	DEG_Kelch_KLHL3_1	0.2222
p.L640P	SIDM00149	Melanoma	GDSC	EPEEPEADQH	DEG_Kelch_KLHL3_1	0.25
p.L640P	ACH-000750	Skin Cancer	CCLE	EPEEPEADQH	DEG_Kelch_KLHL3_1	0.25
p.L640P	LOXIMVI	skin	COSMIC	EPEEPEADQH	DEG_Kelch_KLHL3_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96J92	Serine/threonine-protein kinase WNK4	DEG_Kelch_KLHL3_1	557:566	EPEEPEADQH	CUL3,KLHL3,KLHL2	0.9797	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_Kelch_KLHL3_1	628:637	EPEEPEADQH	CUL3,KLHL3,KLHL2	0.9925	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_Kelch_KLHL3_1	588:597	EPEEPEADQH	CUL3,KLHL3,KLHL2	0.9853	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons