DegronMD

Uniprot ID: Q9Y3S1

Source protein: Serine/threonine-protein kinase WNK2

Source gene: WNK2

Class: DEG_Kelch_KLHL3_1

Location: 588:597

E3 ligase: CUL3,KLHL3,KLHL2

DEGRON score: 0.9853

ASA_SCORE: 103.73

COIL: 0.7891

CONS_SCORE: 0.3714

DSS_SCORE: 0.9165

HELIX: 0.1855

FCONS_SCORE: 1.0635

RIG_SCORE: 0.6111

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P604L	TCGA-2H-A9GJ	ESCA	TCGA	EPEEPEADQH	DEG_Kelch_KLHL3_1	0.1389
p.V591M	DO2162	BRCA	ICGC	EPEEPEADQH	DEG_Kelch_KLHL3_1	0.7208
p.M597I	DO229211	THCA	ICGC	EPEEPEADQH	DEG_Kelch_KLHL3_1	0.7618
p.M597L	DO229240	THCA	ICGC	EPEEPEADQH	DEG_Kelch_KLHL3_1	0.711

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96J92	Serine/threonine-protein kinase WNK4	DEG_Kelch_KLHL3_1	557:566	EPEEPEADQH	CUL3,KLHL3,KLHL2	0.9797	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_Kelch_KLHL3_1	628:637	EPEEPEADQH	CUL3,KLHL3,KLHL2	0.9925	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_Kelch_KLHL3_1	588:597	EPEEPEADQH	CUL3,KLHL3,KLHL2	0.9853	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons