DegronMD - O75916(RGS9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K505N	TCGA-B5-A1MR	UCEC	TCGA	PFSSS	DEG_SPOP_SBC_1	495:499	Mutation substituting flanking lysine	0.2778
p.G485V	TCGA-D3-A8GQ	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.0556
p.A508T	TCGA-D5-6928	COAD	TCGA	PFSSS	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.0833
p.P495S	TCGA-EB-A431	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	495:499	Mutation altering degron motif	0.6752
p.P492S	TCGA-EE-A29E	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.25
p.P492S	TCGA-GF-A6C9	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.25
p.P492S	DO37671	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.25
p.P503H	TCGA-ER-A19B	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.2222
p.P503H	DO220857	MELA	ICGC	PFSSS	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.2222
p.A505T	DO7776	COAD	ICGC	PFSSS	DEG_SPOP_SBC_1	495:499	Mutation substituting flanking lysine	0.2778
p.S491I	DO228952	LICA	ICGC	PFSSS	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.2222
p.R509L	DO229009	LICA	ICGC	PFSSS	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.0556
p.P489S	DO222875	MELA	ICGC	PFSSS	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.1667
p.P489S	DO37831	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.1667
p.P489S	DO51254	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.1667
p.R498C	DO229462	SKCA	ICGC	PFSSS	DEG_SPOP_SBC_1	495:499	Mutation altering degron motif	0.8301
p.R498C	C3A	liver	COSMIC	PFSSS	DEG_SPOP_SBC_1	495:499	Mutation altering degron motif	0.8301
p.P500H	DO47491	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.3056
p.K502N	DO41758	UCEC	ICGC	PFSSS	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.25
p.R501C	SIDM01237	Hepatocellular Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.2778
p.R501C	ACH-001021	Liver Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.2778
p.R501C	C3A	liver	COSMIC	PFSSS	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.2778
p.M488I	SIDM01051	Ovarian Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.1389
p.M488I	ACH-000936	Ovarian Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.1389
p.M488I	EFO-27	ovary	COSMIC	PFSSS	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.1389
p.F507L	SIDM00479	Esophageal Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.1111
p.F507L	ACH-000679	Esophageal Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.1111
p.F507L	OE19	oesophagus	COSMIC	PFSSS	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.1111
p.R501S	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.2778
p.R501S	ACH-000912	Lung Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.2778
p.C500W	ACH-000975	Lung Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.3056
p.F504L	OE19	oesophagus	COSMIC	PFSSS	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.1944
p.M485I	EFO-27	ovary	COSMIC	PFSSS	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.0556

Kaplan plot for RGS9 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RGS9

UniProt ID: O75916

Entrez ID: 8787

Protein name: Regulator of G-protein signaling 9 (RGS9)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RGS9 in