DegronMD

Uniprot ID: O75916

Source protein: Regulator of G-protein signaling 9

Source gene: RGS9

Class: DEG_SPOP_SBC_1

Location: 495:499

E3 ligase: SPOP

DEGRON score: 0.9118

ASA_SCORE: 79.8

COIL: 0.8714

CONS_SCORE: 0.3705

DSS_SCORE: 0.5342

HELIX: 0.1142

FCONS_SCORE: 0.9305

RIG_SCORE: 0.6035

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R498C	DO229462	SKCA	ICGC	PFSSS	DEG_SPOP_SBC_1	0.8301
p.R498C	C3A	liver	COSMIC	PFSSS	DEG_SPOP_SBC_1	0.8301
p.P495S	TCGA-EB-A431	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	0.6752
p.P500H	DO47491	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	0.3056
p.C500W	ACH-000975	Lung Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	0.3056
p.K505N	TCGA-B5-A1MR	UCEC	TCGA	PFSSS	DEG_SPOP_SBC_1	0.2778
p.A505T	DO7776	COAD	ICGC	PFSSS	DEG_SPOP_SBC_1	0.2778
p.R501C	SIDM01237	Hepatocellular Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.2778
p.R501C	ACH-001021	Liver Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	0.2778
p.R501C	C3A	liver	COSMIC	PFSSS	DEG_SPOP_SBC_1	0.2778
p.R501S	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.2778
p.R501S	ACH-000912	Lung Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	0.2778
p.P492S	TCGA-EE-A29E	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	0.25
p.P492S	TCGA-GF-A6C9	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	0.25
p.P492S	DO37671	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	0.25
p.K502N	DO41758	UCEC	ICGC	PFSSS	DEG_SPOP_SBC_1	0.25
p.P503H	TCGA-ER-A19B	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	0.2222
p.P503H	DO220857	MELA	ICGC	PFSSS	DEG_SPOP_SBC_1	0.2222
p.S491I	DO228952	LICA	ICGC	PFSSS	DEG_SPOP_SBC_1	0.2222
p.F504L	OE19	oesophagus	COSMIC	PFSSS	DEG_SPOP_SBC_1	0.1944
p.P489S	DO222875	MELA	ICGC	PFSSS	DEG_SPOP_SBC_1	0.1667
p.P489S	DO37831	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	0.1667
p.P489S	DO51254	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	0.1667
p.M488I	SIDM01051	Ovarian Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.M488I	ACH-000936	Ovarian Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	0.1389

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Drug responses associated with RGS9 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PFSSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N6G6	ADAMTS-like protein 1	DEG_SPOP_SBC_1	836:840	PFSSS	SPOP	0.7453	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	2761:2765	PFSSS	SPOP	0.996	More...
Q8IZP9	Adhesion G-protein coupled receptor G2	DEG_SPOP_SBC_1	254:258	PFSSS	SPOP	0.786	More...
Q68DE3	Basic helix-loop-helix domain-containing protein USF3	DEG_SPOP_SBC_1	1896:1900	PFSSS	SPOP	0.9564	More...
Q6RI45	Bromodomain and WD repeat-containing protein 3	DEG_SPOP_SBC_1	1518:1522	PFSSS	SPOP	0.8389	More...
P16333	Cytoplasmic protein NCK1	DEG_SPOP_SBC_1	200:204	PFSSS	SPOP	0.8259	More...
P98082	Disabled homolog 2	DEG_SPOP_SBC_1	365:369	PFSSS	SPOP	0.9901	More...
Q9UBC2	Epidermal growth factor receptor substrate 15-like 1	DEG_SPOP_SBC_1	710:714	PFSSS	SPOP	0.9988	More...
O14526	F-BAR domain only protein 1	DEG_SPOP_SBC_1	463:467	PFSSS	SPOP	0.7117	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	826:830	PFSSS	SPOP	0.929	More...
O14686	Histone-lysine N-methyltransferase 2D	DEG_SPOP_SBC_1	3172:3176	PFSSS	SPOP	0.987	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	1367:1371	PFSSS	SPOP	0.6184	More...
Q8NDH2	Leucine-rich repeat transmembrane protein CCDC168	DEG_SPOP_SBC_1	350:354	PFSSS	SPOP	0.9972	More...
Q3SXY7	Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3	DEG_SPOP_SBC_1	414:418	PFSSS	SPOP	0.7392	More...
P33076	MHC class II transactivator	DEG_SPOP_SBC_1	211:215	PFSSS	SPOP	0.9232	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10331:10335	PFSSS	SPOP	0.9441	More...
Q86W28	NACHT, LRR and PYD domains-containing protein 8	DEG_SPOP_SBC_1	13:17	PFSSS	SPOP	0.9844	More...
O15049	NEDD4-binding protein 3	DEG_SPOP_SBC_1	207:211	PFSSS	SPOP	0.9962	More...
Q9NX40	OCIA domain-containing protein 1	DEG_SPOP_SBC_1	163:167	PFSSS	SPOP	0.9989	More...
Q9ULL1	Pleckstrin homology domain-containing family G member 1	DEG_SPOP_SBC_1	61:65	PFSSS	SPOP	0.9867	More...
P0C879	Putative uncharacterized protein FLJ43185	DEG_SPOP_SBC_1	53:57	PFSSS	SPOP	0.9272	More...
O75916	Regulator of G-protein signaling 9	DEG_SPOP_SBC_1	495:499	PFSSS	SPOP	0.9118	More...
O75385	Serine/threonine-protein kinase ULK1	DEG_SPOP_SBC_1	420:424	PFSSS	SPOP	0.9904	More...
Q9BYP7	Serine/threonine-protein kinase WNK3	DEG_SPOP_SBC_1	1144:1148	PFSSS	SPOP	0.938	More...
Q96J92	Serine/threonine-protein kinase WNK4	DEG_SPOP_SBC_1	864:868	PFSSS	SPOP	0.8261	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PFSSS

Degron related mutations and impact score

Drug responses associated with RGS9 mutations

All proteins holding degron of PFSSS