DegronMD

Uniprot ID: Q8N6G6

Source protein: ADAMTS-like protein 1

Source gene: ADAMTSL1

Class: DEG_SPOP_SBC_1

Location: 836:840

E3 ligase: SPOP

DEGRON score: 0.7453

ASA_SCORE: 74.64

COIL: 0.868

CONS_SCORE: 0.4442

DSS_SCORE: 0.1436

HELIX: 0.0978

FCONS_SCORE: 1.3022

RIG_SCORE: 0.7572

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P833L	TCGA-AJ-A3OL	UCEC	TCGA	PFSSS	DEG_SPOP_SBC_1	0.25
p.P833L	DO43001	UCEC	ICGC	PFSSS	DEG_SPOP_SBC_1	0.25
p.L831M	TCGA-AP-A0LM	UCEC	TCGA	PFSSS	DEG_SPOP_SBC_1	0.1944
p.L831M	DO43306	UCEC	ICGC	PFSSS	DEG_SPOP_SBC_1	0.1944
p.R842W	TCGA-XE-A8H5	TGCT	TCGA	PFSSS	DEG_SPOP_SBC_1	0.2778
p.I841F	DO225072	BRCA	ICGC	PFSSS	DEG_SPOP_SBC_1	0.3056
p.I841F	DO227701	BRCA	ICGC	PFSSS	DEG_SPOP_SBC_1	0.3056
p.R842T	DO48197	ESCA	ICGC	PFSSS	DEG_SPOP_SBC_1	0.2778
p.S840C	DO25797	LUAD	ICGC	PFSSS	DEG_SPOP_SBC_1	0.7541
p.S840C	SIDM00128	Head and Neck Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.7541
p.S840C	ACH-002249	Head and Neck Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	0.7541
p.S840C	JHU-011	upper_aerodigestive_tract	COSMIC	PFSSS	DEG_SPOP_SBC_1	0.7541
p.T830A	DO232761	PBCA	ICGC	PFSSS	DEG_SPOP_SBC_1	0.1667
p.S839F	SIDM01203	Other Solid Cancers	GDSC	PFSSS	DEG_SPOP_SBC_1	0.7982
p.S839F	ACH-002291	Embryonal Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	0.7982
p.S839F	NTERA-2_cl_D1	testis	COSMIC	PFSSS	DEG_SPOP_SBC_1	0.7982
p.A847E	SIDM01129	Small Cell Lung Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.A847E	ACH-000816	Lung Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	0.1389
p.A847E	NCI-H524	lung	COSMIC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.N828Y	SIDM01019	Acute Myeloid Leukemia	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1111
p.N828Y	ACH-002258	Leukemia	CCLE	PFSSS	DEG_SPOP_SBC_1	0.1111
p.N828Y	KMOE-2	haematopoietic_and_lymphoid_tissue	COSMIC	PFSSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14526	F-BAR domain only protein 1	DEG_SPOP_SBC_1	463:467	PFSSS	SPOP	0.7117	More...
O14686	Histone-lysine N-methyltransferase 2D	DEG_SPOP_SBC_1	3172:3176	PFSSS	SPOP	0.987	More...
O15049	NEDD4-binding protein 3	DEG_SPOP_SBC_1	207:211	PFSSS	SPOP	0.9962	More...
O43294	Transforming growth factor beta-1-induced transcript 1 protein	DEG_SPOP_SBC_1	78:82	PFSSS	SPOP	0.9307	More...
O75385	Serine/threonine-protein kinase ULK1	DEG_SPOP_SBC_1	420:424	PFSSS	SPOP	0.9904	More...
O75916	Regulator of G-protein signaling 9	DEG_SPOP_SBC_1	495:499	PFSSS	SPOP	0.9118	More...
P16333	Cytoplasmic protein NCK1	DEG_SPOP_SBC_1	200:204	PFSSS	SPOP	0.8259	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	2761:2765	PFSSS	SPOP	0.996	More...
P33076	MHC class II transactivator	DEG_SPOP_SBC_1	211:215	PFSSS	SPOP	0.9232	More...
P98082	Disabled homolog 2	DEG_SPOP_SBC_1	365:369	PFSSS	SPOP	0.9901	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	826:830	PFSSS	SPOP	0.929	More...
Q3SXY7	Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3	DEG_SPOP_SBC_1	414:418	PFSSS	SPOP	0.7392	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	1367:1371	PFSSS	SPOP	0.6184	More...
Q68DE3	Basic helix-loop-helix domain-containing protein USF3	DEG_SPOP_SBC_1	1896:1900	PFSSS	SPOP	0.9564	More...
Q6RI45	Bromodomain and WD repeat-containing protein 3	DEG_SPOP_SBC_1	1518:1522	PFSSS	SPOP	0.8389	More...
Q8IZP9	Adhesion G-protein coupled receptor G2	DEG_SPOP_SBC_1	254:258	PFSSS	SPOP	0.786	More...
Q8N6G6	ADAMTS-like protein 1	DEG_SPOP_SBC_1	836:840	PFSSS	SPOP	0.7453	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10331:10335	PFSSS	SPOP	0.9441	More...
Q96J92	Serine/threonine-protein kinase WNK4	DEG_SPOP_SBC_1	864:868	PFSSS	SPOP	0.8261	More...
Q9BX66	Sorbin and SH3 domain-containing protein 1	DEG_SPOP_SBC_1	941:945	PFSSS	SPOP	0.9991	More...
Q9BYP7	Serine/threonine-protein kinase WNK3	DEG_SPOP_SBC_1	1144:1148	PFSSS	SPOP	0.938	More...
Q9HAK2	Transcription factor COE2	DEG_SPOP_SBC_1	527:531	PFSSS	SPOP	0.7804	More...
Q9NX40	OCIA domain-containing protein 1	DEG_SPOP_SBC_1	163:167	PFSSS	SPOP	0.9989	More...
Q9UBC2	Epidermal growth factor receptor substrate 15-like 1	DEG_SPOP_SBC_1	710:714	PFSSS	SPOP	0.9988	More...
Q9UQR0	Sex comb on midleg-like protein 2	DEG_SPOP_SBC_1	466:470	PFSSS	SPOP	0.9364	More...
Q86W28	NACHT, LRR and PYD domains-containing protein 8	DEG_SPOP_SBC_1	13:17	PFSSS	SPOP	0.9844	More...
Q8NDH2	Leucine-rich repeat transmembrane protein CCDC168	DEG_SPOP_SBC_1	350:354	PFSSS	SPOP	0.9972	More...
Q92545	Transmembrane protein 131	DEG_SPOP_SBC_1	1803:1807	PFSSS	SPOP	0.6327	More...
Q9ULL1	Pleckstrin homology domain-containing family G member 1	DEG_SPOP_SBC_1	61:65	PFSSS	SPOP	0.9867	More...
P0C879	Putative uncharacterized protein FLJ43185	DEG_SPOP_SBC_1	53:57	PFSSS	SPOP	0.9272	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PFSSS

Degron related mutations and impact score

Drug responses associated with ADAMTSL1 mutations

All proteins holding degron of PFSSS