DegronMD

Uniprot ID: P33076

Source protein: MHC class II transactivator

Source gene: CIITA

Class: DEG_SPOP_SBC_1

Location: 211:215

E3 ligase: SPOP

DEGRON score: 0.9232

ASA_SCORE: 87.74

COIL: 0.924

CONS_SCORE: 0.2295

DSS_SCORE: 0.4191

HELIX: 0.0438

FCONS_SCORE: 0.8572

RIG_SCORE: 0.6978

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P211H	TCGA-06-5416	GBM	TCGA	PFSSS	DEG_SPOP_SBC_1	0.7694
p.R201C	TCGA-19-5956	GBM	TCGA	PFSSS	DEG_SPOP_SBC_1	0.0556
p.R201C	DO13863	GBM	ICGC	PFSSS	DEG_SPOP_SBC_1	0.0556
p.S215C	TCGA-22-1016	LUSC	TCGA	PFSSS	DEG_SPOP_SBC_1	0.7541
p.S215C	TCGA-ER-A3PL	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	0.7541
p.S216L	TCGA-B5-A11E	UCEC	TCGA	PFSSS	DEG_SPOP_SBC_1	0.3056
p.S216L	TCGA-EE-A2MR	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	0.3056
p.G225E	TCGA-BF-AAP7	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	0.0556
p.G225E	TCGA-EE-A2MJ	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	0.0556
p.P223H	TCGA-CN-6010	HNSC	TCGA	PFSSS	DEG_SPOP_SBC_1	0.1111
p.M210V	TCGA-DI-A1BU	UCEC	TCGA	PFSSS	DEG_SPOP_SBC_1	0.3056
p.Q213H	DO229028	LICA	ICGC	PFSSS	DEG_SPOP_SBC_1	0.7582
p.V225F	DO229031	LICA	ICGC	PFSSS	DEG_SPOP_SBC_1	0.0556
p.R201H	DO45211	LIRI	ICGC	PFSSS	DEG_SPOP_SBC_1	0.0556
p.R201H	ACH-002025	Colon/Colorectal Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	0.0556
p.V217A	DO26200	LUAD	ICGC	PFSSS	DEG_SPOP_SBC_1	0.2778
p.P219H	DO50097	LUSC	ICGC	PFSSS	DEG_SPOP_SBC_1	0.2222
p.T224I	DO48665	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	0.0833
p.S221N	DO47667	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	0.1667
p.P212S	DO41331	UCEC	ICGC	PFSSS	DEG_SPOP_SBC_1	0.6752
p.M211I	SIDM00395	Neuroblastoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.7618
p.M211I	SIMA	autonomic_ganglia	COSMIC	PFSSS	DEG_SPOP_SBC_1	0.7618
p.S203R	CCK-81	large_intestine	COSMIC	PFSSS	DEG_SPOP_SBC_1	0.1111
p.M210I	SIMA	autonomic_ganglia	COSMIC	PFSSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14526	F-BAR domain only protein 1	DEG_SPOP_SBC_1	463:467	PFSSS	SPOP	0.7117	More...
O14686	Histone-lysine N-methyltransferase 2D	DEG_SPOP_SBC_1	3172:3176	PFSSS	SPOP	0.987	More...
O15049	NEDD4-binding protein 3	DEG_SPOP_SBC_1	207:211	PFSSS	SPOP	0.9962	More...
O43294	Transforming growth factor beta-1-induced transcript 1 protein	DEG_SPOP_SBC_1	78:82	PFSSS	SPOP	0.9307	More...
O75385	Serine/threonine-protein kinase ULK1	DEG_SPOP_SBC_1	420:424	PFSSS	SPOP	0.9904	More...
O75916	Regulator of G-protein signaling 9	DEG_SPOP_SBC_1	495:499	PFSSS	SPOP	0.9118	More...
P16333	Cytoplasmic protein NCK1	DEG_SPOP_SBC_1	200:204	PFSSS	SPOP	0.8259	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	2761:2765	PFSSS	SPOP	0.996	More...
P33076	MHC class II transactivator	DEG_SPOP_SBC_1	211:215	PFSSS	SPOP	0.9232	More...
P98082	Disabled homolog 2	DEG_SPOP_SBC_1	365:369	PFSSS	SPOP	0.9901	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	826:830	PFSSS	SPOP	0.929	More...
Q3SXY7	Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3	DEG_SPOP_SBC_1	414:418	PFSSS	SPOP	0.7392	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	1367:1371	PFSSS	SPOP	0.6184	More...
Q68DE3	Basic helix-loop-helix domain-containing protein USF3	DEG_SPOP_SBC_1	1896:1900	PFSSS	SPOP	0.9564	More...
Q6RI45	Bromodomain and WD repeat-containing protein 3	DEG_SPOP_SBC_1	1518:1522	PFSSS	SPOP	0.8389	More...
Q8IZP9	Adhesion G-protein coupled receptor G2	DEG_SPOP_SBC_1	254:258	PFSSS	SPOP	0.786	More...
Q8N6G6	ADAMTS-like protein 1	DEG_SPOP_SBC_1	836:840	PFSSS	SPOP	0.7453	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10331:10335	PFSSS	SPOP	0.9441	More...
Q96J92	Serine/threonine-protein kinase WNK4	DEG_SPOP_SBC_1	864:868	PFSSS	SPOP	0.8261	More...
Q9BX66	Sorbin and SH3 domain-containing protein 1	DEG_SPOP_SBC_1	941:945	PFSSS	SPOP	0.9991	More...
Q9BYP7	Serine/threonine-protein kinase WNK3	DEG_SPOP_SBC_1	1144:1148	PFSSS	SPOP	0.938	More...
Q9HAK2	Transcription factor COE2	DEG_SPOP_SBC_1	527:531	PFSSS	SPOP	0.7804	More...
Q9NX40	OCIA domain-containing protein 1	DEG_SPOP_SBC_1	163:167	PFSSS	SPOP	0.9989	More...
Q9UBC2	Epidermal growth factor receptor substrate 15-like 1	DEG_SPOP_SBC_1	710:714	PFSSS	SPOP	0.9988	More...
Q9UQR0	Sex comb on midleg-like protein 2	DEG_SPOP_SBC_1	466:470	PFSSS	SPOP	0.9364	More...
Q86W28	NACHT, LRR and PYD domains-containing protein 8	DEG_SPOP_SBC_1	13:17	PFSSS	SPOP	0.9844	More...
Q8NDH2	Leucine-rich repeat transmembrane protein CCDC168	DEG_SPOP_SBC_1	350:354	PFSSS	SPOP	0.9972	More...
Q92545	Transmembrane protein 131	DEG_SPOP_SBC_1	1803:1807	PFSSS	SPOP	0.6327	More...
Q9ULL1	Pleckstrin homology domain-containing family G member 1	DEG_SPOP_SBC_1	61:65	PFSSS	SPOP	0.9867	More...
P0C879	Putative uncharacterized protein FLJ43185	DEG_SPOP_SBC_1	53:57	PFSSS	SPOP	0.9272	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PFSSS

Degron related mutations and impact score

Drug responses associated with CIITA mutations

All proteins holding degron of PFSSS