DegronMD - P33076(CIITA)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P211H	TCGA-06-5416	GBM	TCGA	PFSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.7694
p.R201C	TCGA-19-5956	GBM	TCGA	PFSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.0556
p.R201C	DO13863	GBM	ICGC	PFSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.0556
p.S215C	TCGA-22-1016	LUSC	TCGA	PFSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.7541
p.S215C	TCGA-ER-A3PL	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.7541
p.R283Q	TCGA-76-6664	GBM	TCGA	PGSTS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.3056
p.L1120M	TCGA-AA-3715	COAD	TCGA	SLR	DEG_APCC_TPR_1	1128:1130	Mutation rewiring degron network	0.1111
p.L1120M	DO8018	COAD	ICGC	SLR	DEG_APCC_TPR_1	1128:1130	Mutation rewiring degron network	0.1111
p.D296E	TCGA-AA-3844	COAD	TCGA	PGSTS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1111
p.D296E	ACH-000613	Bone Cancer	CCLE	PGSTS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1111
p.D296E	ACH-001001	Bone Cancer	CCLE	PGSTS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1111
p.D296E	ACH-001094	Myeloma	CCLE	PGSTS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1111
p.D296E	HOS	bone	COSMIC	PGSTS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1111
p.E61K	TCGA-AC-A5XS	BRCA	TCGA	IELYSE	LIG_APCC_ABBA_1	62:67	Mutation rewiring degron network	0.3056
p.E61K	DO50023	BRCA	ICGC	IELYSE	LIG_APCC_ABBA_1	62:67	Mutation rewiring degron network	0.3056
p.E61K	DO51082	PRAD	ICGC	IELYSE	LIG_APCC_ABBA_1	62:67	Mutation rewiring degron network	0.3056
p.S216L	TCGA-B5-A11E	UCEC	TCGA	PFSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.3056
p.S216L	TCGA-EE-A2MR	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.3056
p.G225E	TCGA-BF-AAP7	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.0556
p.G225E	TCGA-EE-A2MJ	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.0556
p.R1126W	TCGA-CG-5728	STAD	TCGA	SLR	DEG_APCC_TPR_1	1128:1130	Mutation rewiring degron network	0.2778
p.R1126W	TCGA-VQ-A91D	STAD	TCGA	SLR	DEG_APCC_TPR_1	1128:1130	Mutation rewiring degron network	0.2778
p.R1126W	DO51783	STAD	ICGC	SLR	DEG_APCC_TPR_1	1128:1130	Mutation rewiring degron network	0.2778
p.R1126W	DO38619	STAD	ICGC	SLR	DEG_APCC_TPR_1	1128:1130	Mutation rewiring degron network	0.2778
p.P223H	TCGA-CN-6010	HNSC	TCGA	PFSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1111
p.P281A	TCGA-CW-6090	KIRC	TCGA	PGSTS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.25
p.M210V	TCGA-DI-A1BU	UCEC	TCGA	PFSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.3056
p.P68S	TCGA-FR-A44A	SKCM	TCGA	IELYSE	LIG_APCC_ABBA_1	62:67	Mutation rewiring degron network	0.3056
p.G58V	TCGA-HE-7130	KIRP	TCGA	IELYSE	LIG_APCC_ABBA_1	62:67	Mutation rewiring degron network	0.2222
p.G58V	DO20776	KIRP	ICGC	IELYSE	LIG_APCC_ABBA_1	62:67	Mutation rewiring degron network	0.2222
p.D69N	TCGA-KR-A7K7	LIHC	TCGA	IELYSE	LIG_APCC_ABBA_1	62:67	Mutation rewiring degron network	0.2778
p.D69N	DO230326	COCA	ICGC	IELYSE	LIG_APCC_ABBA_1	62:67	Mutation rewiring degron network	0.2778
p.D69N	DO49698	LIHC	ICGC	IELYSE	LIG_APCC_ABBA_1	62:67	Mutation rewiring degron network	0.2778
p.D55N	TCGA-W3-A824	SKCM	TCGA	IELYSE	LIG_APCC_ABBA_1	62:67	Mutation rewiring degron network	0.1389
p.D55N	DO51271	SKCM	ICGC	IELYSE	LIG_APCC_ABBA_1	62:67	Mutation rewiring degron network	0.1389
p.E67V	TCGA-ZP-A9CZ	LIHC	TCGA	IELYSE	LIG_APCC_ABBA_1	62:67	Mutation altering degron motif	0.7693
p.L288V	DO500	BLCA	ICGC	PGSTS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.6765
p.W285C	DO229019	LICA	ICGC	PGSTS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7
p.Q213H	DO229028	LICA	ICGC	PFSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.7582
p.V225F	DO229031	LICA	ICGC	PFSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.0556
p.D76Y	DO229041	LICA	ICGC	IELYSE	LIG_APCC_ABBA_1	62:67	Mutation rewiring degron network	0.0833
p.R201H	DO45211	LIRI	ICGC	PFSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.0556
p.R201H	ACH-002025	Colon/Colorectal Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.0556
p.V217A	DO26200	LUAD	ICGC	PFSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.2778
p.P219H	DO50097	LUSC	ICGC	PFSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.2222
p.R1126L	DO46591	OV	ICGC	SLR	DEG_APCC_TPR_1	1128:1130	Mutation rewiring degron network	0.2778
p.A57T	DO232224	PBCA	ICGC	IELYSE	LIG_APCC_ABBA_1	62:67	Mutation rewiring degron network	0.1944
p.T224I	DO48665	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.0833
p.S221N	DO47667	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1667
p.A289D	DO229245	THCA	ICGC	PGSTS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.3056
p.P212S	DO41331	UCEC	ICGC	PFSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.6752
p.D76N	DO229086	UTCA	ICGC	IELYSE	LIG_APCC_ABBA_1	62:67	Mutation rewiring degron network	0.0833
p.P293S	SIDM00405	B-Cell Non-Hodgkin's Lymphoma	GDSC	PGSTS	DEG_SPOP_SBC_1	284:288	Mutation blocking phosphorylation signal	0.6389
p.P293S	SU-DHL-4	haematopoietic and lymphoid tissue	COSMIC	PGSTS	DEG_SPOP_SBC_1	284:288	Mutation blocking phosphorylation signal	0.6389
p.M211I	SIDM00395	Neuroblastoma	GDSC	PFSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.7618
p.M211I	SIMA	autonomic ganglia	COSMIC	PFSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.7618
p.T280A	SIDM00717	Non-Cancerous	GDSC	PGSTS	DEG_SPOP_SBC_1	284:288	Mutation blocking phosphorylation signal	0.6667
p.T280A	SIDM00733	Small Cell Lung Carcinoma	GDSC	PGSTS	DEG_SPOP_SBC_1	284:288	Mutation blocking phosphorylation signal	0.6667
p.Q1118R	SIDM00782	Colorectal Carcinoma	GDSC	SLR	DEG_APCC_TPR_1	1128:1130	Mutation rewiring degron network	0.0556
p.Q1118R	T84	large intestine	COSMIC	SLR	DEG_APCC_TPR_1	1128:1130	Mutation rewiring degron network	0.0556
p.D55G	SIDM00562	Breast Carcinoma	GDSC	IELYSE	LIG_APCC_ABBA_1	62:67	Mutation rewiring degron network	0.1389
p.D55G	MRK-nu-1	breast	COSMIC	IELYSE	LIG_APCC_ABBA_1	62:67	Mutation rewiring degron network	0.1389
p.D297E	SIDM00806	Osteosarcoma	GDSC	PGSTS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.0833
p.D297E	HOS	bone	COSMIC	PGSTS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.0833
p.P293A	SIDM01033	Bladder Carcinoma	GDSC	PGSTS	DEG_SPOP_SBC_1	284:288	Mutation blocking phosphorylation signal	0.6389
p.P293A	KU-19-19	urinary tract	COSMIC	PGSTS	DEG_SPOP_SBC_1	284:288	Mutation blocking phosphorylation signal	0.6389
p.R284W	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	PGSTS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.8634
p.R297K	SIDM00784	Glioma	GDSC	PGSTS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.0833
p.L67P	SIDM01774	Pancreatic Carcinoma	GDSC	IELYSE	LIG_APCC_ABBA_1	62:67	Mutation altering degron motif	0.7582
p.P292S	ACH-000365	Lymphoma	CCLE	PGSTS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.2222
p.P292S	SU-DHL-4	haematopoietic and lymphoid tissue	COSMIC	PGSTS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.2222
p.P292A	ACH-000486	Bladder Cancer	CCLE	PGSTS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.2222
p.P292A	KU-19-19	urinary tract	COSMIC	PGSTS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.2222
p.R283W	ACH-000925	Lung Cancer	CCLE	PGSTS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.3056
p.S203R	CCK-81	large intestine	COSMIC	PFSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1111
p.M210I	SIMA	autonomic ganglia	COSMIC	PFSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.3056

Kaplan plot for CIITA in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CIITA

UniProt ID: P33076

Entrez ID: 4261

Protein name: MHC class II transactivator (CIITA) (EC 2.3.1.-) (EC 2.7.11.1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CIITA in