DegronMD

Uniprot ID: P33076

Source protein: MHC class II transactivator

Source gene: CIITA

Class: DEG_SPOP_SBC_1

Location: 284:288

E3 ligase: SPOP

DEGRON score: 0.9991

ASA_SCORE: 74.1

COIL: 0.965

CONS_SCORE: 0.5018

DSS_SCORE: 0.7319

HELIX: 0.0184

FCONS_SCORE: 1.2856

RIG_SCORE: 0.5173

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R283Q	TCGA-76-6664	GBM	TCGA	PGSTS	DEG_SPOP_SBC_1	0.3056
p.D296E	TCGA-AA-3844	COAD	TCGA	PGSTS	DEG_SPOP_SBC_1	0.1111
p.D296E	ACH-000613	Bone Cancer	CCLE	PGSTS	DEG_SPOP_SBC_1	0.1111
p.D296E	ACH-001001	Bone Cancer	CCLE	PGSTS	DEG_SPOP_SBC_1	0.1111
p.D296E	ACH-001094	Myeloma	CCLE	PGSTS	DEG_SPOP_SBC_1	0.1111
p.D296E	HOS	bone	COSMIC	PGSTS	DEG_SPOP_SBC_1	0.1111
p.P281A	TCGA-CW-6090	KIRC	TCGA	PGSTS	DEG_SPOP_SBC_1	0.25
p.L288V	DO500	BLCA	ICGC	PGSTS	DEG_SPOP_SBC_1	0.6765
p.W285C	DO229019	LICA	ICGC	PGSTS	DEG_SPOP_SBC_1	0.7
p.A289D	DO229245	THCA	ICGC	PGSTS	DEG_SPOP_SBC_1	0.3056
p.P293S	SIDM00405	B-Cell Non-Hodgkin's Lymphoma	GDSC	PGSTS	DEG_SPOP_SBC_1	0.6389
p.P293S	SU-DHL-4	haematopoietic_and_lymphoid_tissue	COSMIC	PGSTS	DEG_SPOP_SBC_1	0.6389
p.T280A	SIDM00717	Non-Cancerous	GDSC	PGSTS	DEG_SPOP_SBC_1	0.6667
p.T280A	SIDM00733	Small Cell Lung Carcinoma	GDSC	PGSTS	DEG_SPOP_SBC_1	0.6667
p.D297E	SIDM00806	Osteosarcoma	GDSC	PGSTS	DEG_SPOP_SBC_1	0.0833
p.D297E	HOS	bone	COSMIC	PGSTS	DEG_SPOP_SBC_1	0.0833
p.P293A	SIDM01033	Bladder Carcinoma	GDSC	PGSTS	DEG_SPOP_SBC_1	0.6389
p.P293A	KU-19-19	urinary_tract	COSMIC	PGSTS	DEG_SPOP_SBC_1	0.6389
p.R284W	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	PGSTS	DEG_SPOP_SBC_1	0.8634
p.R297K	SIDM00784	Glioma	GDSC	PGSTS	DEG_SPOP_SBC_1	0.0833
p.P292S	ACH-000365	Lymphoma	CCLE	PGSTS	DEG_SPOP_SBC_1	0.2222
p.P292S	SU-DHL-4	haematopoietic_and_lymphoid_tissue	COSMIC	PGSTS	DEG_SPOP_SBC_1	0.2222
p.P292A	ACH-000486	Bladder Cancer	CCLE	PGSTS	DEG_SPOP_SBC_1	0.2222
p.P292A	KU-19-19	urinary_tract	COSMIC	PGSTS	DEG_SPOP_SBC_1	0.2222
p.R283W	ACH-000925	Lung Cancer	CCLE	PGSTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00444	Serine/threonine-protein kinase PLK4	DEG_SPOP_SBC_1	807:811	PGSTS	SPOP	0.9916	More...
O43159	Ribosomal RNA-processing protein 8	DEG_SPOP_SBC_1	172:176	PGSTS	SPOP	0.9713	More...
O76039	Cyclin-dependent kinase-like 5	DEG_SPOP_SBC_1	390:394	PGSTS	SPOP	0.9869	More...
P33076	MHC class II transactivator	DEG_SPOP_SBC_1	284:288	PGSTS	SPOP	0.9991	More...
P45974	Ubiquitin carboxyl-terminal hydrolase 5	DEG_SPOP_SBC_1	713:717	PGSTS	SPOP	0.8563	More...
P53814	Smoothelin	DEG_SPOP_SBC_1	195:199	PGSTS	SPOP	0.5525	More...
P56696	Potassium voltage-gated channel subfamily KQT member 4	DEG_SPOP_SBC_1	421:425	PGSTS	SPOP	0.8114	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	1853:1857	PGSTS	SPOP	0.9915	More...
Q03989	AT-rich interactive domain-containing protein 5A	DEG_SPOP_SBC_1	122:126	PGSTS	SPOP	0.9788	More...
Q12852	Mitogen-activated protein kinase kinase kinase 12	DEG_SPOP_SBC_1	650:654	PGSTS	SPOP	0.9557	More...
Q14721	Potassium voltage-gated channel subfamily B member 1	DEG_SPOP_SBC_1	779:783	PGSTS	SPOP	0.985	More...
Q14865	AT-rich interactive domain-containing protein 5B	DEG_SPOP_SBC_1	385:389	PGSTS	SPOP	0.9096	More...
Q6RFH5	WD repeat-containing protein 74	DEG_SPOP_SBC_1	380:384	PGSTS	SPOP	0.9317	More...
Q8N5S9	Calcium/calmodulin-dependent protein kinase kinase 1	DEG_SPOP_SBC_1	55:59	PGSTS	SPOP	0.9992	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7333:7337	PGSTS	SPOP	0.9942	More...
Q96KQ4	Apoptosis-stimulating of p53 protein 1	DEG_SPOP_SBC_1	473:477	PGSTS	SPOP	0.986	More...
Q9H1V8	Sodium-dependent neutral amino acid transporter SLC6A17	DEG_SPOP_SBC_1	697:701	PGSTS	SPOP	0.9984	More...
Q9NQW1	Protein transport protein Sec31B	DEG_SPOP_SBC_1	925:929	PGSTS	SPOP	0.9889	More...
Q9NYV4	Cyclin-dependent kinase 12	DEG_SPOP_SBC_1	266:270	PGSTS	SPOP	0.9741	More...
Q9NYZ3	G2 and S phase-expressed protein 1	DEG_SPOP_SBC_1	301:305	PGSTS	SPOP	0.9993	More...
Q9P0L0	Vesicle-associated membrane protein-associated protein A	DEG_SPOP_SBC_1	212:216	PGSTS	SPOP	0.8559	More...
Q9P209	Centrosomal protein of 72 kDa	DEG_SPOP_SBC_1	212:216	PGSTS	SPOP	0.9405	More...
Q9UJY5	ADP-ribosylation factor-binding protein GGA1	DEG_SPOP_SBC_1	313:317	PGSTS	SPOP	0.8423	More...
Q9UPA5	Protein bassoon	DEG_SPOP_SBC_1	73:77	PGSTS	SPOP	0.7536	More...
Q96T92	Insulinoma-associated protein 2	DEG_SPOP_SBC_1	414:418	PGSTS	SPOP	0.9525	More...
O75157	TSC22 domain family protein 2	DEG_SPOP_SBC_1	752:756	PGSTS	SPOP	0.9353	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGSTS

Degron related mutations and impact score

Drug responses associated with CIITA mutations

All proteins holding degron of PGSTS