DegronMD - Q9P209(CEP72)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E205K	TCGA-63-A5MR	LUSC	TCGA	PGSTS	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.1389
p.E205K	TCGA-LA-A446	LUSC	TCGA	PGSTS	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.1389
p.E205K	DO45450	LUSC	ICGC	PGSTS	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.1389
p.E205K	DO219159	LUSC	ICGC	PGSTS	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.1389
p.D302Y	TCGA-A5-A0G1	UCEC	TCGA	FTPHPD	LIG_APCC_ABBA_1	297:302	Mutation altering degron motif	0.7325
p.E223D	TCGA-A5-A0G2	UCEC	TCGA	PGSTS	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.1389
p.E223D	DO41235	UCEC	ICGC	PGSTS	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.1389
p.S309L	TCGA-A5-A0G2	UCEC	TCGA	FTPHPD	LIG_APCC_ABBA_1	297:302	Mutation rewiring degron network	0.1389
p.S309L	TCGA-CV-6935	HNSC	TCGA	FTPHPD	LIG_APCC_ABBA_1	297:302	Mutation rewiring degron network	0.1389
p.S309L	DO15238	HNSC	ICGC	FTPHPD	LIG_APCC_ABBA_1	297:302	Mutation rewiring degron network	0.1389
p.S309L	DO41235	UCEC	ICGC	FTPHPD	LIG_APCC_ABBA_1	297:302	Mutation rewiring degron network	0.1389
p.R222C	TCGA-AZ-6598	COAD	TCGA	PGSTS	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.1667
p.R222C	DO10276	COAD	ICGC	PGSTS	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.1667
p.R222C	DO233210	GACA	ICGC	PGSTS	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.1667
p.R222C	DO228138	PBCA	ICGC	PGSTS	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.1667
p.S214N	TCGA-B5-A0JY	UCEC	TCGA	PGSTS	DEG_SPOP_SBC_1	212:216	Mutation altering degron motif	0.7069
p.S214N	DO43041	UCEC	ICGC	PGSTS	DEG_SPOP_SBC_1	212:216	Mutation altering degron motif	0.7069
p.S216G	TCGA-BR-8382	STAD	TCGA	PGSTS	DEG_SPOP_SBC_1	212:216	Mutation altering degron motif	0.6993
p.S216G	DO47925	STAD	ICGC	PGSTS	DEG_SPOP_SBC_1	212:216	Mutation altering degron motif	0.6993
p.S216G	ACH-001664	Gastric Cancer	CCLE	PGSTS	DEG_SPOP_SBC_1	212:216	Mutation altering degron motif	0.6993
p.S311C	TCGA-BT-A0YX	BLCA	TCGA	FTPHPD	LIG_APCC_ABBA_1	297:302	Mutation rewiring degron network	0.0833
p.S311C	DO516	BLCA	ICGC	FTPHPD	LIG_APCC_ABBA_1	297:302	Mutation rewiring degron network	0.0833
p.R292K	TCGA-D1-A17Q	UCEC	TCGA	FTPHPD	LIG_APCC_ABBA_1	297:302	Mutation rewiring degron network	0.1944
p.R292K	DO41903	UCEC	ICGC	FTPHPD	LIG_APCC_ABBA_1	297:302	Mutation rewiring degron network	0.1944
p.P285S	TCGA-EB-A5SG	SKCM	TCGA	PPLY	ITCH	278:281	Mutation rewiring degron network	0.2222
p.P285S	DO48726	SKCM	ICGC	PPLY	ITCH	278:281	Mutation rewiring degron network	0.2222
p.R289H	TCGA-EY-A215	UCEC	TCGA	FTPHPD	LIG_APCC_ABBA_1	297:302	Mutation rewiring degron network	0.1111
p.R289H	TCGA-EY-A215	UCEC	TCGA	PPLY	ITCH	278:281	Mutation rewiring degron network	0.1111
p.R289H	DO42665	UCEC	ICGC	FTPHPD	LIG_APCC_ABBA_1	297:302	Mutation rewiring degron network	0.1111
p.R289H	DO42665	UCEC	ICGC	PPLY	ITCH	278:281	Mutation rewiring degron network	0.1111
p.S226C	TCGA-FU-A23K	CESC	TCGA	PGSTS	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.0556
p.S226C	DO6305	CESC	ICGC	PGSTS	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.0556
p.S226C	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	PGSTS	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.0556
p.S226C	SIDM00505	Pancreatic Carcinoma	GDSC	PGSTS	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.0556
p.S226C	SIDM01182	Bladder Carcinoma	GDSC	PGSTS	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.0556
p.E286Q	TCGA-IR-A3LK	CESC	TCGA	PPLY	ITCH	278:281	Mutation rewiring degron network	0.1944
p.E286Q	DO44299	CESC	ICGC	PPLY	ITCH	278:281	Mutation rewiring degron network	0.1944
p.G282R	DO233791	GACA	ICGC	PPLY	ITCH	278:281	Mutation rewiring degron network	0.3056
p.G282R	DO48682	LIRI	ICGC	PPLY	ITCH	278:281	Mutation rewiring degron network	0.3056
p.G209V	DO45047	LINC	ICGC	PGSTS	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.25
p.R289C	DO222696	MELA	ICGC	FTPHPD	LIG_APCC_ABBA_1	297:302	Mutation rewiring degron network	0.1111
p.R289C	DO222696	MELA	ICGC	PPLY	ITCH	278:281	Mutation rewiring degron network	0.1111
p.S303F	DO232224	PBCA	ICGC	FTPHPD	LIG_APCC_ABBA_1	297:302	Mutation rewiring degron network	0.3056
p.A283E	DO229208	THCA	ICGC	PPLY	ITCH	278:281	Mutation rewiring degron network	0.2778
p.D207G	SIDM02039	Colorectal Carcinoma	GDSC	PGSTS	DEG_SPOP_SBC_1	212:216	Mutation rewiring degron network	0.1944
p.P269S	SIDM00611	Kidney Carcinoma	GDSC	PPLY	ITCH	278:281	Mutation rewiring degron network	0.0833
p.P269S	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	PPLY	ITCH	278:281	Mutation rewiring degron network	0.0833
p.P269S	SIDM01413	Oral Cavity Carcinoma	GDSC	PPLY	ITCH	278:281	Mutation rewiring degron network	0.0833
p.P269S	RERF-LC-Sq1	lung	COSMIC	PPLY	ITCH	278:281	Mutation rewiring degron network	0.0833
p.P269S	KMRC-1	kidney	COSMIC	PPLY	ITCH	278:281	Mutation rewiring degron network	0.0833
p.T298A	SIDM00878	Breast Carcinoma	GDSC	FTPHPD	LIG_APCC_ABBA_1	297:302	Mutation altering degron motif	0.6028
p.T298A	ACH-000930	Breast Cancer	CCLE	FTPHPD	LIG_APCC_ABBA_1	297:302	Mutation altering degron motif	0.6028
p.T298A	HCC1569	breast	COSMIC	FTPHPD	LIG_APCC_ABBA_1	297:302	Mutation altering degron motif	0.6028
p.Y296H	SIDM01051	Ovarian Carcinoma	GDSC	FTPHPD	LIG_APCC_ABBA_1	297:302	Mutation rewiring degron network	0.3056
p.Y296H	EFO-27	ovary	COSMIC	FTPHPD	LIG_APCC_ABBA_1	297:302	Mutation rewiring degron network	0.3056
p.P278L	ACH-001142	Non-Cancerous	CCLE	PPLY	ITCH	278:281	Mutation altering degron motif	0.7582
p.P278L	ACH-001536	Bile Duct Cancer	CCLE	PPLY	ITCH	278:281	Mutation altering degron motif	0.7582
p.G213R	ACH-001431	Bone Cancer	CCLE	PGSTS	DEG_SPOP_SBC_1	212:216	Mutation altering degron motif	0.6457

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CEP72

UniProt ID: Q9P209

Entrez ID: 55722

Protein name: Centrosomal protein of 72 kDa (Cep72)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CEP72 in