DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
FTPHPD
Uniprot ID:
Q9P209
Source protein:
Centrosomal protein of 72 kDa
Source gene:
CEP72
Class:
LIG_APCC_ABBA_1
Location:
297:302
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9813
ASA_SCORE:
85.7833
COIL:
0.8618
CONS_SCORE:
0.4763
DSS_SCORE:
0.7049
HELIX:
0.0782
FCONS_SCORE:
1.0912
RIG_SCORE:
0.6328
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D302Y
TCGA-A5-A0G1
UCEC
TCGA
FTPHPD
LIG_APCC_ABBA_1
0.7325
p.S309L
TCGA-A5-A0G2
UCEC
TCGA
FTPHPD
LIG_APCC_ABBA_1
0.1389
p.S309L
TCGA-CV-6935
HNSC
TCGA
FTPHPD
LIG_APCC_ABBA_1
0.1389
p.S309L
DO15238
HNSC
ICGC
FTPHPD
LIG_APCC_ABBA_1
0.1389
p.S309L
DO41235
UCEC
ICGC
FTPHPD
LIG_APCC_ABBA_1
0.1389
p.S311C
TCGA-BT-A0YX
BLCA
TCGA
FTPHPD
LIG_APCC_ABBA_1
0.0833
p.S311C
DO516
BLCA
ICGC
FTPHPD
LIG_APCC_ABBA_1
0.0833
p.R292K
TCGA-D1-A17Q
UCEC
TCGA
FTPHPD
LIG_APCC_ABBA_1
0.1944
p.R292K
DO41903
UCEC
ICGC
FTPHPD
LIG_APCC_ABBA_1
0.1944
p.R289H
TCGA-EY-A215
UCEC
TCGA
FTPHPD
LIG_APCC_ABBA_1
0.1111
p.R289H
DO42665
UCEC
ICGC
FTPHPD
LIG_APCC_ABBA_1
0.1111
p.R289C
DO222696
MELA
ICGC
FTPHPD
LIG_APCC_ABBA_1
0.1111
p.S303F
DO232224
PBCA
ICGC
FTPHPD
LIG_APCC_ABBA_1
0.3056
p.T298A
SIDM00878
Breast Carcinoma
GDSC
FTPHPD
LIG_APCC_ABBA_1
0.6028
p.T298A
ACH-000930
Breast Cancer
CCLE
FTPHPD
LIG_APCC_ABBA_1
0.6028
p.T298A
HCC1569
breast
COSMIC
FTPHPD
LIG_APCC_ABBA_1
0.6028
p.Y296H
SIDM01051
Ovarian Carcinoma
GDSC
FTPHPD
LIG_APCC_ABBA_1
0.3056
p.Y296H
EFO-27
ovary
COSMIC
FTPHPD
LIG_APCC_ABBA_1
0.3056
Drug responses associated with CEP72 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of FTPHPD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9P209
Centrosomal protein of 72 kDa
LIG_APCC_ABBA_1
297:302
FTPHPD
APC,CDC20,FZR1
0.9813
More...