DegronMD

Uniprot ID: Q9P209

Source protein: Centrosomal protein of 72 kDa

Source gene: CEP72

Class: LIG_APCC_ABBA_1

Location: 297:302

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9813

ASA_SCORE: 85.7833

COIL: 0.8618

CONS_SCORE: 0.4763

DSS_SCORE: 0.7049

HELIX: 0.0782

FCONS_SCORE: 1.0912

RIG_SCORE: 0.6328

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D302Y	TCGA-A5-A0G1	UCEC	TCGA	FTPHPD	LIG_APCC_ABBA_1	0.7325
p.T298A	SIDM00878	Breast Carcinoma	GDSC	FTPHPD	LIG_APCC_ABBA_1	0.6028
p.T298A	ACH-000930	Breast Cancer	CCLE	FTPHPD	LIG_APCC_ABBA_1	0.6028
p.T298A	HCC1569	breast	COSMIC	FTPHPD	LIG_APCC_ABBA_1	0.6028
p.S303F	DO232224	PBCA	ICGC	FTPHPD	LIG_APCC_ABBA_1	0.3056
p.Y296H	SIDM01051	Ovarian Carcinoma	GDSC	FTPHPD	LIG_APCC_ABBA_1	0.3056
p.Y296H	EFO-27	ovary	COSMIC	FTPHPD	LIG_APCC_ABBA_1	0.3056
p.R292K	TCGA-D1-A17Q	UCEC	TCGA	FTPHPD	LIG_APCC_ABBA_1	0.1944
p.R292K	DO41903	UCEC	ICGC	FTPHPD	LIG_APCC_ABBA_1	0.1944
p.S309L	TCGA-A5-A0G2	UCEC	TCGA	FTPHPD	LIG_APCC_ABBA_1	0.1389
p.S309L	TCGA-CV-6935	HNSC	TCGA	FTPHPD	LIG_APCC_ABBA_1	0.1389
p.S309L	DO15238	HNSC	ICGC	FTPHPD	LIG_APCC_ABBA_1	0.1389
p.S309L	DO41235	UCEC	ICGC	FTPHPD	LIG_APCC_ABBA_1	0.1389
p.R289H	TCGA-EY-A215	UCEC	TCGA	FTPHPD	LIG_APCC_ABBA_1	0.1111
p.R289H	DO42665	UCEC	ICGC	FTPHPD	LIG_APCC_ABBA_1	0.1111
p.R289C	DO222696	MELA	ICGC	FTPHPD	LIG_APCC_ABBA_1	0.1111
p.S311C	TCGA-BT-A0YX	BLCA	TCGA	FTPHPD	LIG_APCC_ABBA_1	0.0833
p.S311C	DO516	BLCA	ICGC	FTPHPD	LIG_APCC_ABBA_1	0.0833

Showing 1 to 18 of 18 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P209	Centrosomal protein of 72 kDa	LIG_APCC_ABBA_1	297:302	FTPHPD	APC,CDC20,FZR1	0.9813	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons