DegronMD - Q12852(MAP3K12)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E39K	TCGA-20-1686	OV	TCGA	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	33:40	Mutation altering degron motif	0.591
p.E39K	DO31380	OV	ICGC	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	33:40	Mutation altering degron motif	0.591
p.Q46R	TCGA-A5-A1OF	UCEC	TCGA	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	33:40	Mutation rewiring degron network	0.1667
p.Q46R	DO42568	UCEC	ICGC	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	33:40	Mutation rewiring degron network	0.1667
p.S643P	TCGA-CD-A48C	STAD	TCGA	PGSTS	DEG_SPOP_SBC_1	650:654	Mutation rewiring degron network	0.1389
p.D664N	TCGA-CR-6484	HNSC	TCGA	PGSTS	DEG_SPOP_SBC_1	650:654	Mutation rewiring degron network	0.0556
p.D664N	DO15206	HNSC	ICGC	PGSTS	DEG_SPOP_SBC_1	650:654	Mutation rewiring degron network	0.0556
p.G661E	TCGA-DU-5870	LGG	TCGA	PGSTS	DEG_SPOP_SBC_1	650:654	Mutation rewiring degron network	0.1389
p.G661E	DO22199	LGG	ICGC	PGSTS	DEG_SPOP_SBC_1	650:654	Mutation rewiring degron network	0.1389
p.R27H	TCGA-EO-A22U	UCEC	TCGA	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	33:40	Mutation rewiring degron network	0.1667
p.R27H	DO43755	UCEC	ICGC	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	33:40	Mutation rewiring degron network	0.1667
p.R656W	TCGA-OR-A5LJ	ACC	TCGA	PGSTS	DEG_SPOP_SBC_1	650:654	Mutation rewiring degron network	0.2778
p.A24T	DO233101	GACA	ICGC	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	33:40	Mutation rewiring degron network	0.0833
p.R656Q	DO233267	GACA	ICGC	PGSTS	DEG_SPOP_SBC_1	650:654	Mutation rewiring degron network	0.2778
p.R656Q	SIDM02072	Colorectal Carcinoma	GDSC	PGSTS	DEG_SPOP_SBC_1	650:654	Mutation rewiring degron network	0.2778
p.A650E	DO228948	LICA	ICGC	PGSTS	DEG_SPOP_SBC_1	650:654	Mutation altering degron motif	0.7701
p.A650E	DO229257	THCA	ICGC	PGSTS	DEG_SPOP_SBC_1	650:654	Mutation altering degron motif	0.7701
p.D30E	DO229018	LICA	ICGC	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	33:40	Mutation rewiring degron network	0.25
p.R27S	DO229028	LICA	ICGC	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	33:40	Mutation rewiring degron network	0.1667
p.P31Q	DO229035	LICA	ICGC	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	33:40	Mutation rewiring degron network	0.2778
p.T659I	DO229211	THCA	ICGC	PGSTS	DEG_SPOP_SBC_1	650:654	Mutation rewiring degron network	0.1944
p.R27C	SIDM01123	Prostate Carcinoma	GDSC	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	33:40	Mutation rewiring degron network	0.1667
p.R27C	ACH-000177	Prostate Cancer	CCLE	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	33:40	Mutation rewiring degron network	0.1667
p.R27C	NCI-H660	prostate	COSMIC	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	33:40	Mutation rewiring degron network	0.1667
p.Q46H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	33:40	Mutation rewiring degron network	0.1667
p.Q46H	ACH-002256	Leukemia	CCLE	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	33:40	Mutation rewiring degron network	0.1667
p.Q46H	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	33:40	Mutation rewiring degron network	0.1667
p.L29M	SIDM00293	Small Cell Lung Carcinoma	GDSC	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	33:40	Mutation rewiring degron network	0.2222
p.L29M	ACH-002052	Lung Cancer	CCLE	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	33:40	Mutation rewiring degron network	0.2222
p.L29M	LU-139	lung	COSMIC	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	33:40	Mutation rewiring degron network	0.2222
p.G661R	SIDM00674	Non-Cancerous	GDSC	PGSTS	DEG_SPOP_SBC_1	650:654	Mutation rewiring degron network	0.1389
p.G661R	SIDM00675	Breast Carcinoma	GDSC	PGSTS	DEG_SPOP_SBC_1	650:654	Mutation rewiring degron network	0.1389
p.G661R	ACH-002377	Non-Cancerous	CCLE	PGSTS	DEG_SPOP_SBC_1	650:654	Mutation rewiring degron network	0.1389
p.D41V	SIDM00980	Gastric Carcinoma	GDSC	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	33:40	Mutation rewiring degron network	0.3056
p.D41V	ACH-000948	Gastric Cancer	CCLE	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	33:40	Mutation rewiring degron network	0.3056
p.D41V	23132-87	stomach	COSMIC	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	33:40	Mutation rewiring degron network	0.3056
p.G657R	SIDM01432	Kidney Carcinoma	GDSC	PGSTS	DEG_SPOP_SBC_1	650:654	Mutation rewiring degron network	0.25
p.G657R	ACH-000495	Kidney Cancer	CCLE	PGSTS	DEG_SPOP_SBC_1	650:654	Mutation rewiring degron network	0.25
p.G651D	ACH-000920	Leukemia	CCLE	PGSTS	DEG_SPOP_SBC_1	650:654	Mutation altering degron motif	0.6087
p.G651D	CML-T1	haematopoietic and lymphoid tissue	COSMIC	PGSTS	DEG_SPOP_SBC_1	650:654	Mutation altering degron motif	0.6087

Kaplan plot for MAP3K12 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAP3K12

UniProt ID: Q12852

Entrez ID: 7786

Protein name: Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Dual leucine zipper bearing kinase) (DLK) (Leucine-zipper protein kinase) (ZPK) (MAPK-upstream kinase) (MUK) (Mixed lineage kinase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAP3K12 in