DegronMD

Uniprot ID: Q12852

Source protein: Mitogen-activated protein kinase kinase kinase 12

Source gene: MAP3K12

Class: DEG_SCF_SKP2-CKS1_1

Location: 33:40

E3 ligase: SKP2,CSK1

DEGRON score: 0.9887

ASA_SCORE: 85.225

COIL: 0.8778

CONS_SCORE: 0.2843

DSS_SCORE: 0.6616

HELIX: 0.0751

FCONS_SCORE: 1.0772

RIG_SCORE: 0.6977

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E39K	TCGA-20-1686	OV	TCGA	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	0.591
p.E39K	DO31380	OV	ICGC	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	0.591
p.Q46R	TCGA-A5-A1OF	UCEC	TCGA	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	0.1667
p.Q46R	DO42568	UCEC	ICGC	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	0.1667
p.R27H	TCGA-EO-A22U	UCEC	TCGA	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	0.1667
p.R27H	DO43755	UCEC	ICGC	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	0.1667
p.A24T	DO233101	GACA	ICGC	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	0.0833
p.D30E	DO229018	LICA	ICGC	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	0.25
p.R27S	DO229028	LICA	ICGC	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	0.1667
p.P31Q	DO229035	LICA	ICGC	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	0.2778
p.R27C	SIDM01123	Prostate Carcinoma	GDSC	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	0.1667
p.R27C	ACH-000177	Prostate Cancer	CCLE	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	0.1667
p.R27C	NCI-H660	prostate	COSMIC	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	0.1667
p.Q46H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	0.1667
p.Q46H	ACH-002256	Leukemia	CCLE	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	0.1667
p.Q46H	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	0.1667
p.L29M	SIDM00293	Small Cell Lung Carcinoma	GDSC	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	0.2222
p.L29M	ACH-002052	Lung Cancer	CCLE	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	0.2222
p.L29M	LU-139	lung	COSMIC	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	0.2222
p.D41V	SIDM00980	Gastric Carcinoma	GDSC	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	0.3056
p.D41V	ACH-000948	Gastric Cancer	CCLE	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	0.3056
p.D41V	23132-87	stomach	COSMIC	TSDCTPEK	DEG_SCF_SKP2-CKS1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12852	Mitogen-activated protein kinase kinase kinase 12	DEG_SCF_SKP2-CKS1_1	33:40	TSDCTPEK	SKP2,CSK1	0.9887	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons