DegronMD

Uniprot ID: Q12852

Source protein: Mitogen-activated protein kinase kinase kinase 12

Source gene: MAP3K12

Class: DEG_SPOP_SBC_1

Location: 650:654

E3 ligase: SPOP

DEGRON score: 0.9557

ASA_SCORE: 76.24

COIL: 0.9572

CONS_SCORE: 0.2593

DSS_SCORE: 0.8856

HELIX: 0.0164

FCONS_SCORE: 0.9522

RIG_SCORE: 0.4269

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S643P	TCGA-CD-A48C	STAD	TCGA	PGSTS	DEG_SPOP_SBC_1	0.1389
p.D664N	TCGA-CR-6484	HNSC	TCGA	PGSTS	DEG_SPOP_SBC_1	0.0556
p.D664N	DO15206	HNSC	ICGC	PGSTS	DEG_SPOP_SBC_1	0.0556
p.G661E	TCGA-DU-5870	LGG	TCGA	PGSTS	DEG_SPOP_SBC_1	0.1389
p.G661E	DO22199	LGG	ICGC	PGSTS	DEG_SPOP_SBC_1	0.1389
p.R656W	TCGA-OR-A5LJ	ACC	TCGA	PGSTS	DEG_SPOP_SBC_1	0.2778
p.R656Q	DO233267	GACA	ICGC	PGSTS	DEG_SPOP_SBC_1	0.2778
p.R656Q	SIDM02072	Colorectal Carcinoma	GDSC	PGSTS	DEG_SPOP_SBC_1	0.2778
p.A650E	DO228948	LICA	ICGC	PGSTS	DEG_SPOP_SBC_1	0.7701
p.A650E	DO229257	THCA	ICGC	PGSTS	DEG_SPOP_SBC_1	0.7701
p.T659I	DO229211	THCA	ICGC	PGSTS	DEG_SPOP_SBC_1	0.1944
p.G661R	SIDM00674	Non-Cancerous	GDSC	PGSTS	DEG_SPOP_SBC_1	0.1389
p.G661R	SIDM00675	Breast Carcinoma	GDSC	PGSTS	DEG_SPOP_SBC_1	0.1389
p.G661R	ACH-002377	Non-Cancerous	CCLE	PGSTS	DEG_SPOP_SBC_1	0.1389
p.G657R	SIDM01432	Kidney Carcinoma	GDSC	PGSTS	DEG_SPOP_SBC_1	0.25
p.G657R	ACH-000495	Kidney Cancer	CCLE	PGSTS	DEG_SPOP_SBC_1	0.25
p.G651D	ACH-000920	Leukemia	CCLE	PGSTS	DEG_SPOP_SBC_1	0.6087
p.G651D	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PGSTS	DEG_SPOP_SBC_1	0.6087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00444	Serine/threonine-protein kinase PLK4	DEG_SPOP_SBC_1	807:811	PGSTS	SPOP	0.9916	More...
O43159	Ribosomal RNA-processing protein 8	DEG_SPOP_SBC_1	172:176	PGSTS	SPOP	0.9713	More...
O76039	Cyclin-dependent kinase-like 5	DEG_SPOP_SBC_1	390:394	PGSTS	SPOP	0.9869	More...
P33076	MHC class II transactivator	DEG_SPOP_SBC_1	284:288	PGSTS	SPOP	0.9991	More...
P45974	Ubiquitin carboxyl-terminal hydrolase 5	DEG_SPOP_SBC_1	713:717	PGSTS	SPOP	0.8563	More...
P53814	Smoothelin	DEG_SPOP_SBC_1	195:199	PGSTS	SPOP	0.5525	More...
P56696	Potassium voltage-gated channel subfamily KQT member 4	DEG_SPOP_SBC_1	421:425	PGSTS	SPOP	0.8114	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	1853:1857	PGSTS	SPOP	0.9915	More...
Q03989	AT-rich interactive domain-containing protein 5A	DEG_SPOP_SBC_1	122:126	PGSTS	SPOP	0.9788	More...
Q12852	Mitogen-activated protein kinase kinase kinase 12	DEG_SPOP_SBC_1	650:654	PGSTS	SPOP	0.9557	More...
Q14721	Potassium voltage-gated channel subfamily B member 1	DEG_SPOP_SBC_1	779:783	PGSTS	SPOP	0.985	More...
Q14865	AT-rich interactive domain-containing protein 5B	DEG_SPOP_SBC_1	385:389	PGSTS	SPOP	0.9096	More...
Q6RFH5	WD repeat-containing protein 74	DEG_SPOP_SBC_1	380:384	PGSTS	SPOP	0.9317	More...
Q8N5S9	Calcium/calmodulin-dependent protein kinase kinase 1	DEG_SPOP_SBC_1	55:59	PGSTS	SPOP	0.9992	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7333:7337	PGSTS	SPOP	0.9942	More...
Q96KQ4	Apoptosis-stimulating of p53 protein 1	DEG_SPOP_SBC_1	473:477	PGSTS	SPOP	0.986	More...
Q9H1V8	Sodium-dependent neutral amino acid transporter SLC6A17	DEG_SPOP_SBC_1	697:701	PGSTS	SPOP	0.9984	More...
Q9NQW1	Protein transport protein Sec31B	DEG_SPOP_SBC_1	925:929	PGSTS	SPOP	0.9889	More...
Q9NYV4	Cyclin-dependent kinase 12	DEG_SPOP_SBC_1	266:270	PGSTS	SPOP	0.9741	More...
Q9NYZ3	G2 and S phase-expressed protein 1	DEG_SPOP_SBC_1	301:305	PGSTS	SPOP	0.9993	More...
Q9P0L0	Vesicle-associated membrane protein-associated protein A	DEG_SPOP_SBC_1	212:216	PGSTS	SPOP	0.8559	More...
Q9P209	Centrosomal protein of 72 kDa	DEG_SPOP_SBC_1	212:216	PGSTS	SPOP	0.9405	More...
Q9UJY5	ADP-ribosylation factor-binding protein GGA1	DEG_SPOP_SBC_1	313:317	PGSTS	SPOP	0.8423	More...
Q9UPA5	Protein bassoon	DEG_SPOP_SBC_1	73:77	PGSTS	SPOP	0.7536	More...
Q96T92	Insulinoma-associated protein 2	DEG_SPOP_SBC_1	414:418	PGSTS	SPOP	0.9525	More...
O75157	TSC22 domain family protein 2	DEG_SPOP_SBC_1	752:756	PGSTS	SPOP	0.9353	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGSTS

Degron related mutations and impact score

Drug responses associated with MAP3K12 mutations

All proteins holding degron of PGSTS