DegronMD - Q9UJY5(GGA1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K165N	TCGA-19-5956	GBM	TCGA	KNVIFED	LIG_APCC_ABBAyCdc20_2	165:171	Mutation altering degron motif	0.6918
p.I168L	TCGA-AA-A010	COAD	TCGA	KNVIFED	LIG_APCC_ABBAyCdc20_2	165:171	Mutation altering degron motif	0.6063
p.L327P	TCGA-AB-2805	LAML	TCGA	PGSTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.0556
p.R180H	TCGA-EO-A22U	UCEC	TCGA	KNVIFED	LIG_APCC_ABBAyCdc20_2	165:171	Mutation rewiring degron network	0.0833
p.R180H	ACH-000995	Leukemia	CCLE	KNVIFED	LIG_APCC_ABBAyCdc20_2	165:171	Mutation rewiring degron network	0.0833
p.P451S	TCGA-FR-A7U9	SKCM	TCGA	PRLTLRDLQ	DEG_APCC_DBOX_1	451:459	Mutation altering degron motif	0.5641
p.P451S	TCGA-FR-A7U9	SKCM	TCGA	PTPRLT	DEG_SCF_FBW7_1	449:454	Mutation altering degron motif	0.6752
p.L320P	TCGA-HU-A4G9	STAD	TCGA	PGSTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.25
p.A465T	DO48381	BLCA	ICGC	PRLTLRDLQ	DEG_APCC_DBOX_1	451:459	Mutation rewiring degron network	0.1667
p.A159T	DO3095	BRCA	ICGC	KNVIFED	LIG_APCC_ABBAyCdc20_2	165:171	Mutation rewiring degron network	0.1667
p.P459S	DO219728	CESC	ICGC	PRLTLRDLQ	DEG_APCC_DBOX_1	451:459	Mutation altering degron motif	0.6752
p.H444R	DO10443	COAD	ICGC	PRLTLRDLQ	DEG_APCC_DBOX_1	451:459	Mutation rewiring degron network	0.1389
p.H444R	DO10443	COAD	ICGC	PTPRLT	DEG_SCF_FBW7_1	449:454	Mutation rewiring degron network	0.1944
p.G256S	DO10373	COAD	ICGC	MRPTLFRLA	DEG_APCC_DBOX_1	259:267	Mutation rewiring degron network	0.25
p.P454L	DO227985	COCA	ICGC	PRLTLRDLQ	DEG_APCC_DBOX_1	451:459	Mutation altering degron motif	0.7582
p.P454L	DO227985	COCA	ICGC	PTPRLT	DEG_SCF_FBW7_1	449:454	Mutation altering degron motif	0.7582
p.P454L	DO48174	UCEC	ICGC	PRLTLRDLQ	DEG_APCC_DBOX_1	451:459	Mutation altering degron motif	0.7582
p.P454L	DO48174	UCEC	ICGC	PTPRLT	DEG_SCF_FBW7_1	449:454	Mutation altering degron motif	0.7582
p.P454L	DO43306	UCEC	ICGC	PRLTLRDLQ	DEG_APCC_DBOX_1	451:459	Mutation altering degron motif	0.7582
p.P454L	DO43306	UCEC	ICGC	PTPRLT	DEG_SCF_FBW7_1	449:454	Mutation altering degron motif	0.7582
p.S262N	DO10880	GBM	ICGC	MRPTLFRLA	DEG_APCC_DBOX_1	259:267	Mutation altering degron motif	0.7069
p.S262N	SIDM00287	B-Lymphoblastic Leukemia	GDSC	MRPTLFRLA	DEG_APCC_DBOX_1	259:267	Mutation altering degron motif	0.7069
p.S262N	SIDM00503	Gastric Carcinoma	GDSC	MRPTLFRLA	DEG_APCC_DBOX_1	259:267	Mutation altering degron motif	0.7069
p.S262N	SIDM01727	Chronic Myelogenous Leukemia	GDSC	MRPTLFRLA	DEG_APCC_DBOX_1	259:267	Mutation altering degron motif	0.7069
p.S262N	SIDM01377	Ovarian Carcinoma	GDSC	MRPTLFRLA	DEG_APCC_DBOX_1	259:267	Mutation altering degron motif	0.7069
p.S262N	SIDM01433	Kidney Carcinoma	GDSC	MRPTLFRLA	DEG_APCC_DBOX_1	259:267	Mutation altering degron motif	0.7069
p.S262N	BALL-1	haematopoietic and lymphoid tissue	COSMIC	MRPTLFRLA	DEG_APCC_DBOX_1	259:267	Mutation altering degron motif	0.7069
p.S262N	FU97	stomach	COSMIC	MRPTLFRLA	DEG_APCC_DBOX_1	259:267	Mutation altering degron motif	0.7069
p.I467M	DO49055	HNSC	ICGC	PRLTLRDLQ	DEG_APCC_DBOX_1	451:459	Mutation rewiring degron network	0.1111
p.S441I	DO228974	LICA	ICGC	PRLTLRDLQ	DEG_APCC_DBOX_1	451:459	Mutation rewiring degron network	0.0556
p.S441I	DO228974	LICA	ICGC	PTPRLT	DEG_SCF_FBW7_1	449:454	Mutation rewiring degron network	0.1111
p.G277C	DO229029	LICA	ICGC	MRPTLFRLA	DEG_APCC_DBOX_1	259:267	Mutation rewiring degron network	0.0556
p.D323Y	DO229028	LICA	ICGC	PGSTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.1667
p.G160V	DO229037	LICA	ICGC	KNVIFED	LIG_APCC_ABBAyCdc20_2	165:171	Mutation rewiring degron network	0.1944
p.D171G	DO49657	LIHC	ICGC	KNVIFED	LIG_APCC_ABBAyCdc20_2	165:171	Mutation altering degron motif	0.7198
p.N251S	DO231566	LINC	ICGC	MRPTLFRLA	DEG_APCC_DBOX_1	259:267	Mutation rewiring degron network	0.1111
p.R460L	DO231862	LINC	ICGC	PRLTLRDLQ	DEG_APCC_DBOX_1	451:459	Mutation rewiring degron network	0.3056
p.R460L	DO231862	LINC	ICGC	PTPRLT	DEG_SCF_FBW7_1	449:454	Mutation rewiring degron network	0.1667
p.R307C	DO219184	LUSC	ICGC	PGSTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.1667
p.R266L	DO37567	SKCM	ICGC	MRPTLFRLA	DEG_APCC_DBOX_1	259:267	Mutation altering degron motif	0.8428
p.P468S	DO48546	SKCM	ICGC	PRLTLRDLQ	DEG_APCC_DBOX_1	451:459	Mutation rewiring degron network	0.0833
p.P468S	ACH-001203	Lymphoma	CCLE	PRLTLRDLQ	DEG_APCC_DBOX_1	451:459	Mutation rewiring degron network	0.0833
p.P468S	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	PRLTLRDLQ	DEG_APCC_DBOX_1	451:459	Mutation rewiring degron network	0.0833
p.T305I	DO37727	SKCM	ICGC	PGSTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.1111
p.D165N	DO47829	STAD	ICGC	KNVIFED	LIG_APCC_ABBAyCdc20_2	165:171	Mutation altering degron motif	0.6932
p.D165N	DO43899	UCEC	ICGC	KNVIFED	LIG_APCC_ABBAyCdc20_2	165:171	Mutation altering degron motif	0.6932
p.D165N	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	KNVIFED	LIG_APCC_ABBAyCdc20_2	165:171	Mutation altering degron motif	0.6932
p.D165N	SIDM00276	Biliary Tract Carcinoma	GDSC	KNVIFED	LIG_APCC_ABBAyCdc20_2	165:171	Mutation altering degron motif	0.6932
p.D165N	SIDM00233	T-Lymphoblastic Leukemia	GDSC	KNVIFED	LIG_APCC_ABBAyCdc20_2	165:171	Mutation altering degron motif	0.6932
p.D165N	SIDM01412	Oral Cavity Carcinoma	GDSC	KNVIFED	LIG_APCC_ABBAyCdc20_2	165:171	Mutation altering degron motif	0.6932
p.D165N	PC-14	lung	COSMIC	KNVIFED	LIG_APCC_ABBAyCdc20_2	165:171	Mutation altering degron motif	0.6932
p.D165N	ETK-1	biliary tract	COSMIC	KNVIFED	LIG_APCC_ABBAyCdc20_2	165:171	Mutation altering degron motif	0.6932
p.D165N	ATN-1	haematopoietic and lymphoid tissue	COSMIC	KNVIFED	LIG_APCC_ABBAyCdc20_2	165:171	Mutation altering degron motif	0.6932
p.S179P	DO41361	UCEC	ICGC	KNVIFED	LIG_APCC_ABBAyCdc20_2	165:171	Mutation rewiring degron network	0.1111
p.P453S	DO41331	UCEC	ICGC	PRLTLRDLQ	DEG_APCC_DBOX_1	451:459	Mutation altering degron motif	0.6752
p.P453S	DO41331	UCEC	ICGC	PTPRLT	DEG_SCF_FBW7_1	449:454	Mutation altering degron motif	0.6752
p.M155I	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	KNVIFED	LIG_APCC_ABBAyCdc20_2	165:171	Mutation rewiring degron network	0.0556
p.M155I	T-T	oesophagus	COSMIC	KNVIFED	LIG_APCC_ABBAyCdc20_2	165:171	Mutation rewiring degron network	0.0556
p.V307M	SIDM00330	Neuroblastoma	GDSC	PGSTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.1667
p.V307M	LAN-6	autonomic ganglia	COSMIC	PGSTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.1667
p.R460W	SIDM00602	Gastric Carcinoma	GDSC	PRLTLRDLQ	DEG_APCC_DBOX_1	451:459	Mutation rewiring degron network	0.3056
p.R460W	SIDM00602	Gastric Carcinoma	GDSC	PTPRLT	DEG_SCF_FBW7_1	449:454	Mutation rewiring degron network	0.1667
p.R460W	IM-95	stomach	COSMIC	PRLTLRDLQ	DEG_APCC_DBOX_1	451:459	Mutation rewiring degron network	0.3056
p.R460W	IM-95	stomach	COSMIC	PTPRLT	DEG_SCF_FBW7_1	449:454	Mutation rewiring degron network	0.1667
p.P181L	SIDM01240	Melanoma	GDSC	KNVIFED	LIG_APCC_ABBAyCdc20_2	165:171	Mutation rewiring degron network	0.0556
p.P181L	451Lu	skin	COSMIC	KNVIFED	LIG_APCC_ABBAyCdc20_2	165:171	Mutation rewiring degron network	0.0556
p.R316W	SIDM01057	Acute Myeloid Leukemia	GDSC	PGSTS	DEG_SPOP_SBC_1	313:317	Mutation altering degron motif	0.8634
p.R316W	GDM-1	haematopoietic and lymphoid tissue	COSMIC	PGSTS	DEG_SPOP_SBC_1	313:317	Mutation altering degron motif	0.8634
p.F174V	SIDM00282	Colorectal Carcinoma	GDSC	KNVIFED	LIG_APCC_ABBAyCdc20_2	165:171	Mutation blocking ubiquitination signal	0.6944
p.F174V	CW-2	large intestine	COSMIC	KNVIFED	LIG_APCC_ABBAyCdc20_2	165:171	Mutation blocking ubiquitination signal	0.6944
p.V162I	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	KNVIFED	LIG_APCC_ABBAyCdc20_2	165:171	Mutation rewiring degron network	0.25
p.V162I	SIDM00863	Burkitt's Lymphoma	GDSC	KNVIFED	LIG_APCC_ABBAyCdc20_2	165:171	Mutation rewiring degron network	0.25
p.S463G	ACH-000345	Neuroblastoma	CCLE	PRLTLRDLQ	DEG_APCC_DBOX_1	451:459	Mutation rewiring degron network	0.2222
p.S463G	ACH-000345	Neuroblastoma	CCLE	PTPRLT	DEG_SCF_FBW7_1	449:454	Mutation rewiring degron network	0.0833
p.S463G	ACH-002163	Breast Cancer	CCLE	PRLTLRDLQ	DEG_APCC_DBOX_1	451:459	Mutation rewiring degron network	0.2222
p.S463G	ACH-002163	Breast Cancer	CCLE	PTPRLT	DEG_SCF_FBW7_1	449:454	Mutation rewiring degron network	0.0833
p.S463G	KP-N-RT-BM-1	autonomic ganglia	COSMIC	PRLTLRDLQ	DEG_APCC_DBOX_1	451:459	Mutation rewiring degron network	0.2222
p.S463G	KP-N-RT-BM-1	autonomic ganglia	COSMIC	PTPRLT	DEG_SCF_FBW7_1	449:454	Mutation rewiring degron network	0.0833
p.S463G	MRK-nu-1	breast	COSMIC	PRLTLRDLQ	DEG_APCC_DBOX_1	451:459	Mutation rewiring degron network	0.2222
p.S463G	MRK-nu-1	breast	COSMIC	PTPRLT	DEG_SCF_FBW7_1	449:454	Mutation rewiring degron network	0.0833
p.R443W	ACH-000919	Gastric Cancer	CCLE	PRLTLRDLQ	DEG_APCC_DBOX_1	451:459	Mutation rewiring degron network	0.1111
p.R443W	ACH-000919	Gastric Cancer	CCLE	PTPRLT	DEG_SCF_FBW7_1	449:454	Mutation rewiring degron network	0.1667
p.R443W	IM-95	stomach	COSMIC	PRLTLRDLQ	DEG_APCC_DBOX_1	451:459	Mutation rewiring degron network	0.1111
p.R443W	IM-95	stomach	COSMIC	PTPRLT	DEG_SCF_FBW7_1	449:454	Mutation rewiring degron network	0.1667
p.A276V	ACH-000935	Colon/Colorectal Cancer	CCLE	MRPTLFRLA	DEG_APCC_DBOX_1	259:267	Mutation rewiring degron network	0.0833
p.F157V	ACH-000998	Colon/Colorectal Cancer	CCLE	KNVIFED	LIG_APCC_ABBAyCdc20_2	165:171	Mutation rewiring degron network	0.1111
p.F157V	CW-2	large intestine	COSMIC	KNVIFED	LIG_APCC_ABBAyCdc20_2	165:171	Mutation rewiring degron network	0.1111
p.P164L	ACH-001002	Skin Cancer	CCLE	KNVIFED	LIG_APCC_ABBAyCdc20_2	165:171	Mutation rewiring degron network	0.3056
p.P164L	451Lu	skin	COSMIC	KNVIFED	LIG_APCC_ABBAyCdc20_2	165:171	Mutation rewiring degron network	0.3056
p.D274H	ACH-001694	Head and Neck Cancer	CCLE	MRPTLFRLA	DEG_APCC_DBOX_1	259:267	Mutation rewiring degron network	0.1389
p.M460V	EN	endometrium	COSMIC	PRLTLRDLQ	DEG_APCC_DBOX_1	451:459	Mutation rewiring degron network	0.3056
p.M460V	EN	endometrium	COSMIC	PTPRLT	DEG_SCF_FBW7_1	449:454	Mutation rewiring degron network	0.1667
p.R469H	Hs-578-T	breast	COSMIC	PRLTLRDLQ	DEG_APCC_DBOX_1	451:459	Mutation rewiring degron network	0.0556
p.Q324E	OCUM-1	stomach	COSMIC	PGSTS	DEG_SPOP_SBC_1	313:317	Mutation rewiring degron network	0.1389
p.S315L	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PGSTS	DEG_SPOP_SBC_1	313:317	Mutation altering degron motif	0.7667
p.A257V	HeLa	cervix	COSMIC	MRPTLFRLA	DEG_APCC_DBOX_1	259:267	Mutation rewiring degron network	0.2778
p.S172N	BALL-1	haematopoietic and lymphoid tissue	COSMIC	KNVIFED	LIG_APCC_ABBAyCdc20_2	165:171	Mutation rewiring degron network	0.3056
p.S172N	FU97	stomach	COSMIC	KNVIFED	LIG_APCC_ABBAyCdc20_2	165:171	Mutation rewiring degron network	0.3056
p.R451H	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PRLTLRDLQ	DEG_APCC_DBOX_1	451:459	Mutation altering degron motif	0.8244
p.R451H	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PTPRLT	DEG_SCF_FBW7_1	449:454	Mutation altering degron motif	0.8244
p.R451H	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PRLTLRDLQ	DEG_APCC_DBOX_1	451:459	Mutation altering degron motif	0.8244
p.R451H	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PTPRLT	DEG_SCF_FBW7_1	449:454	Mutation altering degron motif	0.8244

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GGA1

UniProt ID: Q9UJY5

Entrez ID: 26088

Protein name: ADP-ribosylation factor-binding protein GGA1 (Gamma-adaptin-related protein 1) (Golgi-localized, gamma ear-containing, ARF-binding protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GGA1 in