DegronMD

Uniprot ID: Q9UJY5

Source protein: ADP-ribosylation factor-binding protein GGA1

Source gene: GGA1

Class: DEG_SCF_FBW7_1

Location: 449:454

E3 ligase: FBXW7

DEGRON score: 0.9982

ASA_SCORE: 80.6833

COIL: 0.8597

CONS_SCORE: 0.2849

DSS_SCORE: 0.6315

HELIX: 0.088

FCONS_SCORE: 1.0603

RIG_SCORE: 0.7293

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P451S	TCGA-FR-A7U9	SKCM	TCGA	PTPRLT	DEG_SCF_FBW7_1	0.6752
p.H444R	DO10443	COAD	ICGC	PTPRLT	DEG_SCF_FBW7_1	0.1944
p.P454L	DO227985	COCA	ICGC	PTPRLT	DEG_SCF_FBW7_1	0.7582
p.P454L	DO48174	UCEC	ICGC	PTPRLT	DEG_SCF_FBW7_1	0.7582
p.P454L	DO43306	UCEC	ICGC	PTPRLT	DEG_SCF_FBW7_1	0.7582
p.S441I	DO228974	LICA	ICGC	PTPRLT	DEG_SCF_FBW7_1	0.1111
p.R460L	DO231862	LINC	ICGC	PTPRLT	DEG_SCF_FBW7_1	0.1667
p.P453S	DO41331	UCEC	ICGC	PTPRLT	DEG_SCF_FBW7_1	0.6752
p.R460W	SIDM00602	Gastric Carcinoma	GDSC	PTPRLT	DEG_SCF_FBW7_1	0.1667
p.R460W	IM-95	stomach	COSMIC	PTPRLT	DEG_SCF_FBW7_1	0.1667
p.S463G	ACH-000345	Neuroblastoma	CCLE	PTPRLT	DEG_SCF_FBW7_1	0.0833
p.S463G	ACH-002163	Breast Cancer	CCLE	PTPRLT	DEG_SCF_FBW7_1	0.0833
p.S463G	KP-N-RT-BM-1	autonomic_ganglia	COSMIC	PTPRLT	DEG_SCF_FBW7_1	0.0833
p.S463G	MRK-nu-1	breast	COSMIC	PTPRLT	DEG_SCF_FBW7_1	0.0833
p.R443W	ACH-000919	Gastric Cancer	CCLE	PTPRLT	DEG_SCF_FBW7_1	0.1667
p.R443W	IM-95	stomach	COSMIC	PTPRLT	DEG_SCF_FBW7_1	0.1667
p.M460V	EN	endometrium	COSMIC	PTPRLT	DEG_SCF_FBW7_1	0.1667
p.R451H	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PTPRLT	DEG_SCF_FBW7_1	0.8244
p.R451H	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PTPRLT	DEG_SCF_FBW7_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UJY5	ADP-ribosylation factor-binding protein GGA1	DEG_SCF_FBW7_1	449:454	PTPRLT	FBXW7	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons