DegronMD

Uniprot ID: Q9UJY5

Source protein: ADP-ribosylation factor-binding protein GGA1

Source gene: GGA1

Class: DEG_APCC_DBOX_1

Location: 451:459

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9863

ASA_SCORE: 81.4889

COIL: 0.6528

CONS_SCORE: 0.309

DSS_SCORE: 0.6588

HELIX: 0.2961

FCONS_SCORE: 1.1684

RIG_SCORE: 0.7323

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P451S	TCGA-FR-A7U9	SKCM	TCGA	PRLTLRDLQ	DEG_APCC_DBOX_1	0.5641
p.A465T	DO48381	BLCA	ICGC	PRLTLRDLQ	DEG_APCC_DBOX_1	0.1667
p.P459S	DO219728	CESC	ICGC	PRLTLRDLQ	DEG_APCC_DBOX_1	0.6752
p.H444R	DO10443	COAD	ICGC	PRLTLRDLQ	DEG_APCC_DBOX_1	0.1389
p.P454L	DO227985	COCA	ICGC	PRLTLRDLQ	DEG_APCC_DBOX_1	0.7582
p.P454L	DO48174	UCEC	ICGC	PRLTLRDLQ	DEG_APCC_DBOX_1	0.7582
p.P454L	DO43306	UCEC	ICGC	PRLTLRDLQ	DEG_APCC_DBOX_1	0.7582
p.I467M	DO49055	HNSC	ICGC	PRLTLRDLQ	DEG_APCC_DBOX_1	0.1111
p.S441I	DO228974	LICA	ICGC	PRLTLRDLQ	DEG_APCC_DBOX_1	0.0556
p.R460L	DO231862	LINC	ICGC	PRLTLRDLQ	DEG_APCC_DBOX_1	0.3056
p.P468S	DO48546	SKCM	ICGC	PRLTLRDLQ	DEG_APCC_DBOX_1	0.0833
p.P468S	ACH-001203	Lymphoma	CCLE	PRLTLRDLQ	DEG_APCC_DBOX_1	0.0833
p.P468S	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	PRLTLRDLQ	DEG_APCC_DBOX_1	0.0833
p.P453S	DO41331	UCEC	ICGC	PRLTLRDLQ	DEG_APCC_DBOX_1	0.6752
p.R460W	SIDM00602	Gastric Carcinoma	GDSC	PRLTLRDLQ	DEG_APCC_DBOX_1	0.3056
p.R460W	IM-95	stomach	COSMIC	PRLTLRDLQ	DEG_APCC_DBOX_1	0.3056
p.S463G	ACH-000345	Neuroblastoma	CCLE	PRLTLRDLQ	DEG_APCC_DBOX_1	0.2222
p.S463G	ACH-002163	Breast Cancer	CCLE	PRLTLRDLQ	DEG_APCC_DBOX_1	0.2222
p.S463G	KP-N-RT-BM-1	autonomic_ganglia	COSMIC	PRLTLRDLQ	DEG_APCC_DBOX_1	0.2222
p.S463G	MRK-nu-1	breast	COSMIC	PRLTLRDLQ	DEG_APCC_DBOX_1	0.2222
p.R443W	ACH-000919	Gastric Cancer	CCLE	PRLTLRDLQ	DEG_APCC_DBOX_1	0.1111
p.R443W	IM-95	stomach	COSMIC	PRLTLRDLQ	DEG_APCC_DBOX_1	0.1111
p.M460V	EN	endometrium	COSMIC	PRLTLRDLQ	DEG_APCC_DBOX_1	0.3056
p.R469H	Hs-578-T	breast	COSMIC	PRLTLRDLQ	DEG_APCC_DBOX_1	0.0556
p.R451H	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PRLTLRDLQ	DEG_APCC_DBOX_1	0.8244
p.R451H	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PRLTLRDLQ	DEG_APCC_DBOX_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UJY5	ADP-ribosylation factor-binding protein GGA1	DEG_APCC_DBOX_1	451:459	PRLTLRDLQ	APC,CDC20,FZR1	0.9863	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRLTLRDLQ

Degron related mutations and impact score

Drug responses associated with GGA1 mutations

All proteins holding degron of PRLTLRDLQ