DegronMD

Uniprot ID: Q9UJY5

Source protein: ADP-ribosylation factor-binding protein GGA1

Source gene: GGA1

Class: DEG_APCC_DBOX_1

Location: 259:267

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9823

ASA_SCORE: 76.6222

COIL: 0.4782

CONS_SCORE: 0.4877

DSS_SCORE: 0.4041

HELIX: 0.467

FCONS_SCORE: 1.0614

RIG_SCORE: 0.7896

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G256S	DO10373	COAD	ICGC	MRPTLFRLA	DEG_APCC_DBOX_1	0.25
p.S262N	DO10880	GBM	ICGC	MRPTLFRLA	DEG_APCC_DBOX_1	0.7069
p.S262N	SIDM00287	B-Lymphoblastic Leukemia	GDSC	MRPTLFRLA	DEG_APCC_DBOX_1	0.7069
p.S262N	SIDM00503	Gastric Carcinoma	GDSC	MRPTLFRLA	DEG_APCC_DBOX_1	0.7069
p.S262N	SIDM01727	Chronic Myelogenous Leukemia	GDSC	MRPTLFRLA	DEG_APCC_DBOX_1	0.7069
p.S262N	SIDM01377	Ovarian Carcinoma	GDSC	MRPTLFRLA	DEG_APCC_DBOX_1	0.7069
p.S262N	SIDM01433	Kidney Carcinoma	GDSC	MRPTLFRLA	DEG_APCC_DBOX_1	0.7069
p.S262N	BALL-1	haematopoietic_and_lymphoid_tissue	COSMIC	MRPTLFRLA	DEG_APCC_DBOX_1	0.7069
p.S262N	FU97	stomach	COSMIC	MRPTLFRLA	DEG_APCC_DBOX_1	0.7069
p.G277C	DO229029	LICA	ICGC	MRPTLFRLA	DEG_APCC_DBOX_1	0.0556
p.N251S	DO231566	LINC	ICGC	MRPTLFRLA	DEG_APCC_DBOX_1	0.1111
p.R266L	DO37567	SKCM	ICGC	MRPTLFRLA	DEG_APCC_DBOX_1	0.8428
p.A276V	ACH-000935	Colon/Colorectal Cancer	CCLE	MRPTLFRLA	DEG_APCC_DBOX_1	0.0833
p.D274H	ACH-001694	Head and Neck Cancer	CCLE	MRPTLFRLA	DEG_APCC_DBOX_1	0.1389
p.A257V	HeLa	cervix	COSMIC	MRPTLFRLA	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UJY5	ADP-ribosylation factor-binding protein GGA1	DEG_APCC_DBOX_1	259:267	MRPTLFRLA	APC,CDC20,FZR1	0.9823	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons