DegronMD

Uniprot ID: Q9UJY5

Source protein: ADP-ribosylation factor-binding protein GGA1

Source gene: GGA1

Class: LIG_APCC_ABBAyCdc20_2

Location: 165:171

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9336

ASA_SCORE: 105.5429

COIL: 0.7133

CONS_SCORE: 0.4173

DSS_SCORE: 0.5679

HELIX: 0.2564

FCONS_SCORE: 0.8686

RIG_SCORE: 0.7551

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K165N	TCGA-19-5956	GBM	TCGA	KNVIFED	LIG_APCC_ABBAyCdc20_2	0.6918
p.I168L	TCGA-AA-A010	COAD	TCGA	KNVIFED	LIG_APCC_ABBAyCdc20_2	0.6063
p.R180H	TCGA-EO-A22U	UCEC	TCGA	KNVIFED	LIG_APCC_ABBAyCdc20_2	0.0833
p.R180H	ACH-000995	Leukemia	CCLE	KNVIFED	LIG_APCC_ABBAyCdc20_2	0.0833
p.A159T	DO3095	BRCA	ICGC	KNVIFED	LIG_APCC_ABBAyCdc20_2	0.1667
p.G160V	DO229037	LICA	ICGC	KNVIFED	LIG_APCC_ABBAyCdc20_2	0.1944
p.D171G	DO49657	LIHC	ICGC	KNVIFED	LIG_APCC_ABBAyCdc20_2	0.7198
p.D165N	DO47829	STAD	ICGC	KNVIFED	LIG_APCC_ABBAyCdc20_2	0.6932
p.D165N	DO43899	UCEC	ICGC	KNVIFED	LIG_APCC_ABBAyCdc20_2	0.6932
p.D165N	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	KNVIFED	LIG_APCC_ABBAyCdc20_2	0.6932
p.D165N	SIDM00276	Biliary Tract Carcinoma	GDSC	KNVIFED	LIG_APCC_ABBAyCdc20_2	0.6932
p.D165N	SIDM00233	T-Lymphoblastic Leukemia	GDSC	KNVIFED	LIG_APCC_ABBAyCdc20_2	0.6932
p.D165N	SIDM01412	Oral Cavity Carcinoma	GDSC	KNVIFED	LIG_APCC_ABBAyCdc20_2	0.6932
p.D165N	PC-14	lung	COSMIC	KNVIFED	LIG_APCC_ABBAyCdc20_2	0.6932
p.D165N	ETK-1	biliary_tract	COSMIC	KNVIFED	LIG_APCC_ABBAyCdc20_2	0.6932
p.D165N	ATN-1	haematopoietic_and_lymphoid_tissue	COSMIC	KNVIFED	LIG_APCC_ABBAyCdc20_2	0.6932
p.S179P	DO41361	UCEC	ICGC	KNVIFED	LIG_APCC_ABBAyCdc20_2	0.1111
p.M155I	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	KNVIFED	LIG_APCC_ABBAyCdc20_2	0.0556
p.M155I	T-T	oesophagus	COSMIC	KNVIFED	LIG_APCC_ABBAyCdc20_2	0.0556
p.P181L	SIDM01240	Melanoma	GDSC	KNVIFED	LIG_APCC_ABBAyCdc20_2	0.0556
p.P181L	451Lu	skin	COSMIC	KNVIFED	LIG_APCC_ABBAyCdc20_2	0.0556
p.F174V	SIDM00282	Colorectal Carcinoma	GDSC	KNVIFED	LIG_APCC_ABBAyCdc20_2	0.6944
p.F174V	CW-2	large_intestine	COSMIC	KNVIFED	LIG_APCC_ABBAyCdc20_2	0.6944
p.V162I	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	KNVIFED	LIG_APCC_ABBAyCdc20_2	0.25
p.V162I	SIDM00863	Burkitt's Lymphoma	GDSC	KNVIFED	LIG_APCC_ABBAyCdc20_2	0.25
p.F157V	ACH-000998	Colon/Colorectal Cancer	CCLE	KNVIFED	LIG_APCC_ABBAyCdc20_2	0.1111
p.F157V	CW-2	large_intestine	COSMIC	KNVIFED	LIG_APCC_ABBAyCdc20_2	0.1111
p.P164L	ACH-001002	Skin Cancer	CCLE	KNVIFED	LIG_APCC_ABBAyCdc20_2	0.3056
p.P164L	451Lu	skin	COSMIC	KNVIFED	LIG_APCC_ABBAyCdc20_2	0.3056
p.S172N	BALL-1	haematopoietic_and_lymphoid_tissue	COSMIC	KNVIFED	LIG_APCC_ABBAyCdc20_2	0.3056
p.S172N	FU97	stomach	COSMIC	KNVIFED	LIG_APCC_ABBAyCdc20_2	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KNVIFED

Degron related mutations and impact score

Drug responses associated with GGA1 mutations

All proteins holding degron of KNVIFED

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UJY5	ADP-ribosylation factor-binding protein GGA1	LIG_APCC_ABBAyCdc20_2	165:171	KNVIFED	APC,CDC20,FZR1	0.9336	More...