DegronMD - Q6RFH5(WDR74)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L160V	TCGA-05-4424	LUAD	TCGA	GKENA	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.1667
p.L160V	DO23672	LUAD	ICGC	GKENA	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.1667
p.K378T	TCGA-AX-A0J0	UCEC	TCGA	PGSTS	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.2778
p.K378T	DO41133	UCEC	ICGC	PGSTS	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.2778
p.P143S	TCGA-D3-A3C7	SKCM	TCGA	GKENA	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.1389
p.P143S	DO47569	SKCM	ICGC	GKENA	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.1389
p.W158L	TCGA-HE-7128	KIRP	TCGA	GKENA	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.2222
p.W158L	DO20796	KIRP	ICGC	GKENA	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.2222
p.P140Q	TCGA-HE-7130	KIRP	TCGA	GKENA	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.0556
p.P140Q	DO20776	KIRP	ICGC	GKENA	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.0556
p.V146D	SIDM00683	Prostate Carcinoma	GDSC	GKENA	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.2222
p.V146D	ACH-000977	lymph node	CCLE	GKENA	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.2222
p.V146D	LNCaP-Clone-FGC	prostate	COSMIC	GKENA	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.2222
p.R160H	ACH-000200	Brain Cancer	CCLE	GKENA	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.1667
p.R160H	ACH-000919	Gastric Cancer	CCLE	GKENA	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.1667
p.R160H	NMC-G1	central nervous system	COSMIC	GKENA	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.1667
p.R160H	IM-95	stomach	COSMIC	GKENA	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.1667
p.K140E	ACH-000952	Prostate Cancer	CCLE	GKENA	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.0556
p.R160C	GP5d	large intestine	COSMIC	GKENA	DEG_APCC_KENBOX_2	150:154	Mutation rewiring degron network	0.1667

Kaplan plot for WDR74 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WDR74

UniProt ID: Q6RFH5

Entrez ID: 54663

Protein name: WD repeat-containing protein 74 (NOP seven-associated protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WDR74 in