DegronMD

Uniprot ID: Q6RFH5

Source protein: WD repeat-containing protein 74

Source gene: WDR74

Class: DEG_APCC_KENBOX_2

Location: 150:154

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9593

ASA_SCORE: 44.04

COIL: 0.7074

CONS_SCORE: 0.753

DSS_SCORE: 0.3506

HELIX: 0.0066

FCONS_SCORE: 1.1801

RIG_SCORE: 0.727

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L160V	TCGA-05-4424	LUAD	TCGA	GKENA	DEG_APCC_KENBOX_2	0.1667
p.L160V	DO23672	LUAD	ICGC	GKENA	DEG_APCC_KENBOX_2	0.1667
p.P143S	TCGA-D3-A3C7	SKCM	TCGA	GKENA	DEG_APCC_KENBOX_2	0.1389
p.P143S	DO47569	SKCM	ICGC	GKENA	DEG_APCC_KENBOX_2	0.1389
p.W158L	TCGA-HE-7128	KIRP	TCGA	GKENA	DEG_APCC_KENBOX_2	0.2222
p.W158L	DO20796	KIRP	ICGC	GKENA	DEG_APCC_KENBOX_2	0.2222
p.P140Q	TCGA-HE-7130	KIRP	TCGA	GKENA	DEG_APCC_KENBOX_2	0.0556
p.P140Q	DO20776	KIRP	ICGC	GKENA	DEG_APCC_KENBOX_2	0.0556
p.V146D	SIDM00683	Prostate Carcinoma	GDSC	GKENA	DEG_APCC_KENBOX_2	0.2222
p.V146D	ACH-000977	lymph_node	CCLE	GKENA	DEG_APCC_KENBOX_2	0.2222
p.V146D	LNCaP-Clone-FGC	prostate	COSMIC	GKENA	DEG_APCC_KENBOX_2	0.2222
p.R160H	ACH-000200	Brain Cancer	CCLE	GKENA	DEG_APCC_KENBOX_2	0.1667
p.R160H	ACH-000919	Gastric Cancer	CCLE	GKENA	DEG_APCC_KENBOX_2	0.1667
p.R160H	NMC-G1	central_nervous_system	COSMIC	GKENA	DEG_APCC_KENBOX_2	0.1667
p.R160H	IM-95	stomach	COSMIC	GKENA	DEG_APCC_KENBOX_2	0.1667
p.K140E	ACH-000952	Prostate Cancer	CCLE	GKENA	DEG_APCC_KENBOX_2	0.0556
p.R160C	GP5d	large_intestine	COSMIC	GKENA	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6RFH5	WD repeat-containing protein 74	DEG_APCC_KENBOX_2	150:154	GKENA	APC,CDC20,FZR1	0.9593	More...
Q9HCM7	Fibrosin-1-like protein	DEG_APCC_KENBOX_2	43:47	GKENA	APC,CDC20,FZR1	0.9859	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons