DegronMD

Uniprot ID: Q9HCM7

Source protein: Fibrosin-1-like protein

Source gene: FBRSL1

Class: DEG_APCC_KENBOX_2

Location: 43:47

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9859

ASA_SCORE: 90.4

COIL: 0.8304

CONS_SCORE: 0.4082

DSS_SCORE: 0.8756

HELIX: 0.161

FCONS_SCORE: 1.0582

RIG_SCORE: 0.489

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E36D	DO222445	BTCA	ICGC	GKENA	DEG_APCC_KENBOX_2	0.1389
p.R40C	DO233855	GACA	ICGC	GKENA	DEG_APCC_KENBOX_2	0.25
p.R34Q	DO233855	GACA	ICGC	GKENA	DEG_APCC_KENBOX_2	0.5278
p.R34Q	DO229234	THCA	ICGC	GKENA	DEG_APCC_KENBOX_2	0.5278

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6RFH5	WD repeat-containing protein 74	DEG_APCC_KENBOX_2	150:154	GKENA	APC,CDC20,FZR1	0.9593	More...
Q9HCM7	Fibrosin-1-like protein	DEG_APCC_KENBOX_2	43:47	GKENA	APC,CDC20,FZR1	0.9859	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons