DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
FBRSL1
UniProt ID:
Q9HCM7
Entrez ID:
57666
Protein name:
Fibrosin-1-like protein (AUTS2-like protein) (HBV X-transactivated gene 9 protein) (HBV XAg-transactivated protein 9)
External links:
UniprotKB
HGNC
RefSeq
COSMIC
Please click
HERE
for better display.
Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
RNA binding [GO:0003723]...
RNA binding [GO:0003723]
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GO - Cellular component (CC):
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Choose a PDB ID:
Open in full screen with detailed sequence annotations
FBRSL1
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Phosphorylation
Legend: PTM sites
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.E36D
DO222445
BTCA
ICGC
GKENA
DEG_APCC_KENBOX_2
43:47
Mutation rewiring degron network
0.1389
p.R40C
DO233855
GACA
ICGC
GKENA
DEG_APCC_KENBOX_2
43:47
Mutation rewiring degron network
0.25
p.R34Q
DO233855
GACA
ICGC
GKENA
DEG_APCC_KENBOX_2
43:47
Mutation blocking phosphorylation signal
0.5278
p.R34Q
DO229234
THCA
ICGC
GKENA
DEG_APCC_KENBOX_2
43:47
Mutation blocking phosphorylation signal
0.5278
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for FBRSL1 in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc