DegronMD

Uniprot ID: O00444

Source protein: Serine/threonine-protein kinase PLK4

Source gene: PLK4

Class: DEG_SPOP_SBC_1

Location: 807:811

E3 ligase: SPOP

DEGRON score: 0.9916

ASA_SCORE: 79.14

COIL: 0.9706

CONS_SCORE: 0.4164

DSS_SCORE: 0.5385

HELIX: 0.0112

FCONS_SCORE: 0.9159

RIG_SCORE: 0.5496

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F799S	TCGA-A6-6781	COAD	TCGA	PGSTS	DEG_SPOP_SBC_1	0.1111
p.P807S	TCGA-AX-A2HC	UCEC	TCGA	PGSTS	DEG_SPOP_SBC_1	0.6752
p.F798C	TCGA-D9-A6EC	SKCM	TCGA	PGSTS	DEG_SPOP_SBC_1	0.0833
p.S821F	TCGA-DK-AA71	BLCA	TCGA	PGSTS	DEG_SPOP_SBC_1	0.5
p.G808D	TCGA-FS-A4F8	SKCM	TCGA	PGSTS	DEG_SPOP_SBC_1	0.6087
p.G819V	DO228456	LICA	ICGC	PGSTS	DEG_SPOP_SBC_1	0.1111
p.W820L	DO228948	LICA	ICGC	PGSTS	DEG_SPOP_SBC_1	0.0833
p.W820L	DO218860	SKCA	ICGC	PGSTS	DEG_SPOP_SBC_1	0.0833
p.S798I	DO229041	LICA	ICGC	PGSTS	DEG_SPOP_SBC_1	0.0833
p.A807S	DO229008	LICA	ICGC	PGSTS	DEG_SPOP_SBC_1	0.7588
p.W820C	DO52302	LIHC	ICGC	PGSTS	DEG_SPOP_SBC_1	0.0833
p.W820C	DO218966	PAAD	ICGC	PGSTS	DEG_SPOP_SBC_1	0.0833
p.S812T	DO231734	LINC	ICGC	PGSTS	DEG_SPOP_SBC_1	0.3056
p.S812C	DO25847	LUAD	ICGC	PGSTS	DEG_SPOP_SBC_1	0.3056
p.L799I	DO223286	UCEC	ICGC	PGSTS	DEG_SPOP_SBC_1	0.1111
p.I801V	SIDM00084	Glioblastoma	GDSC	PGSTS	DEG_SPOP_SBC_1	0.1667
p.P819S	SIDM01080	Oral Cavity Carcinoma	GDSC	PGSTS	DEG_SPOP_SBC_1	0.1111
p.P819S	SCC-9	upper_aerodigestive_tract	COSMIC	PGSTS	DEG_SPOP_SBC_1	0.1111
p.S806T	HCT-116	large_intestine	COSMIC	PGSTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00444	Serine/threonine-protein kinase PLK4	DEG_SPOP_SBC_1	807:811	PGSTS	SPOP	0.9916	More...
O43159	Ribosomal RNA-processing protein 8	DEG_SPOP_SBC_1	172:176	PGSTS	SPOP	0.9713	More...
O76039	Cyclin-dependent kinase-like 5	DEG_SPOP_SBC_1	390:394	PGSTS	SPOP	0.9869	More...
P33076	MHC class II transactivator	DEG_SPOP_SBC_1	284:288	PGSTS	SPOP	0.9991	More...
P45974	Ubiquitin carboxyl-terminal hydrolase 5	DEG_SPOP_SBC_1	713:717	PGSTS	SPOP	0.8563	More...
P53814	Smoothelin	DEG_SPOP_SBC_1	195:199	PGSTS	SPOP	0.5525	More...
P56696	Potassium voltage-gated channel subfamily KQT member 4	DEG_SPOP_SBC_1	421:425	PGSTS	SPOP	0.8114	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	1853:1857	PGSTS	SPOP	0.9915	More...
Q03989	AT-rich interactive domain-containing protein 5A	DEG_SPOP_SBC_1	122:126	PGSTS	SPOP	0.9788	More...
Q12852	Mitogen-activated protein kinase kinase kinase 12	DEG_SPOP_SBC_1	650:654	PGSTS	SPOP	0.9557	More...
Q14721	Potassium voltage-gated channel subfamily B member 1	DEG_SPOP_SBC_1	779:783	PGSTS	SPOP	0.985	More...
Q14865	AT-rich interactive domain-containing protein 5B	DEG_SPOP_SBC_1	385:389	PGSTS	SPOP	0.9096	More...
Q6RFH5	WD repeat-containing protein 74	DEG_SPOP_SBC_1	380:384	PGSTS	SPOP	0.9317	More...
Q8N5S9	Calcium/calmodulin-dependent protein kinase kinase 1	DEG_SPOP_SBC_1	55:59	PGSTS	SPOP	0.9992	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7333:7337	PGSTS	SPOP	0.9942	More...
Q96KQ4	Apoptosis-stimulating of p53 protein 1	DEG_SPOP_SBC_1	473:477	PGSTS	SPOP	0.986	More...
Q9H1V8	Sodium-dependent neutral amino acid transporter SLC6A17	DEG_SPOP_SBC_1	697:701	PGSTS	SPOP	0.9984	More...
Q9NQW1	Protein transport protein Sec31B	DEG_SPOP_SBC_1	925:929	PGSTS	SPOP	0.9889	More...
Q9NYV4	Cyclin-dependent kinase 12	DEG_SPOP_SBC_1	266:270	PGSTS	SPOP	0.9741	More...
Q9NYZ3	G2 and S phase-expressed protein 1	DEG_SPOP_SBC_1	301:305	PGSTS	SPOP	0.9993	More...
Q9P0L0	Vesicle-associated membrane protein-associated protein A	DEG_SPOP_SBC_1	212:216	PGSTS	SPOP	0.8559	More...
Q9P209	Centrosomal protein of 72 kDa	DEG_SPOP_SBC_1	212:216	PGSTS	SPOP	0.9405	More...
Q9UJY5	ADP-ribosylation factor-binding protein GGA1	DEG_SPOP_SBC_1	313:317	PGSTS	SPOP	0.8423	More...
Q9UPA5	Protein bassoon	DEG_SPOP_SBC_1	73:77	PGSTS	SPOP	0.7536	More...
Q96T92	Insulinoma-associated protein 2	DEG_SPOP_SBC_1	414:418	PGSTS	SPOP	0.9525	More...
O75157	TSC22 domain family protein 2	DEG_SPOP_SBC_1	752:756	PGSTS	SPOP	0.9353	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGSTS

Degron related mutations and impact score

Drug responses associated with PLK4 mutations

All proteins holding degron of PGSTS