DegronMD - P56696(KCNQ4)

KCNQ4

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P421S	TCGA-49-6743	LUAD	TCGA	PGSTS	DEG_SPOP_SBC_1	421:425	Mutation altering degron motif	0.6752
p.P421S	DO26092	LUAD	ICGC	PGSTS	DEG_SPOP_SBC_1	421:425	Mutation altering degron motif	0.6752
p.S431R	TCGA-OR-A5J8	ACC	TCGA	PGSTS	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.1667
p.R420W	DO233115	GACA	ICGC	PGSTS	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.3056
p.R420W	RERF-LC-MS	lung	COSMIC	PGSTS	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.3056
p.R433L	DO228974	LICA	ICGC	PGSTS	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.1111
p.R433L	DO229018	LICA	ICGC	PGSTS	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.1111
p.M434I	DO229027	LICA	ICGC	PGSTS	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.0833
p.E430K	DO50970	LICA	ICGC	PGSTS	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.1944
p.V415I	DO228142	PBCA	ICGC	PGSTS	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.1667
p.Y412S	DO229144	THCA	ICGC	PGSTS	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.0833
p.T435A	CCK-81	large intestine	COSMIC	PGSTS	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.0556
p.Q415R	HCC1569	breast	COSMIC	PGSTS	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.1667
p.R434H	S-117	soft tissue	COSMIC	PGSTS	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc