DegronMD - P45974(USP5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R146W	TCGA-AA-A022	COAD	TCGA	ARDGLGGLP	DEG_APCC_DBOX_1	132:140	Mutation rewiring degron network	0.1667
p.R146W	TCGA-AJ-A5DW	UCEC	TCGA	ARDGLGGLP	DEG_APCC_DBOX_1	132:140	Mutation rewiring degron network	0.1667
p.R146W	TCGA-AP-A1DV	UCEC	TCGA	ARDGLGGLP	DEG_APCC_DBOX_1	132:140	Mutation rewiring degron network	0.1667
p.R146W	DO10647	COAD	ICGC	ARDGLGGLP	DEG_APCC_DBOX_1	132:140	Mutation rewiring degron network	0.1667
p.R146W	DO229221	THCA	ICGC	ARDGLGGLP	DEG_APCC_DBOX_1	132:140	Mutation rewiring degron network	0.1667
p.R146W	DO50075	UCEC	ICGC	ARDGLGGLP	DEG_APCC_DBOX_1	132:140	Mutation rewiring degron network	0.1667
p.R146W	DO43186	UCEC	ICGC	ARDGLGGLP	DEG_APCC_DBOX_1	132:140	Mutation rewiring degron network	0.1667
p.R146W	SIDM00145	T-Lymphoblastic Leukemia	GDSC	ARDGLGGLP	DEG_APCC_DBOX_1	132:140	Mutation rewiring degron network	0.1667
p.R146W	ACH-001127	Leukemia	CCLE	ARDGLGGLP	DEG_APCC_DBOX_1	132:140	Mutation rewiring degron network	0.1667
p.R146W	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	ARDGLGGLP	DEG_APCC_DBOX_1	132:140	Mutation rewiring degron network	0.1667
p.S717R	TCGA-AD-A5EJ	COAD	TCGA	PGSTS	DEG_SPOP_SBC_1	713:717	Mutation altering degron motif	0.7427
p.S717R	DO50090	COAD	ICGC	PGSTS	DEG_SPOP_SBC_1	713:717	Mutation altering degron motif	0.7427
p.D726E	TCGA-AP-A059	UCEC	TCGA	PGSTS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.0833
p.D726E	DO41361	UCEC	ICGC	PGSTS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.0833
p.D721N	TCGA-AP-A1DV	UCEC	TCGA	PGSTS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.2222
p.D721N	DO43186	UCEC	ICGC	PGSTS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.2222
p.I124M	TCGA-B5-A11N	UCEC	TCGA	ARDGLGGLP	DEG_APCC_DBOX_1	132:140	Mutation rewiring degron network	0.1111
p.I124M	DO41458	UCEC	ICGC	ARDGLGGLP	DEG_APCC_DBOX_1	132:140	Mutation rewiring degron network	0.1111
p.A718T	TCGA-BR-8381	STAD	TCGA	PGSTS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.3056
p.A718T	DO47817	STAD	ICGC	PGSTS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.3056
p.N703T	TCGA-EY-A1GK	UCEC	TCGA	PGSTS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.0556
p.N703T	DO42985	UCEC	ICGC	PGSTS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.0556
p.G714C	TCGA-LN-A9FP	ESCA	TCGA	PGSTS	DEG_SPOP_SBC_1	713:717	Mutation altering degron motif	0.6489
p.L705F	DO48467	BLCA	ICGC	PGSTS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.1111
p.D134G	DO227996	COCA	ICGC	ARDGLGGLP	DEG_APCC_DBOX_1	132:140	Mutation altering degron motif	0.6087
p.D127Y	DO229018	LICA	ICGC	ARDGLGGLP	DEG_APCC_DBOX_1	132:140	Mutation rewiring degron network	0.1944
p.P723H	DO45277	LIRI	ICGC	PGSTS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.1667
p.V147L	DO232073	ORCA	ICGC	ARDGLGGLP	DEG_APCC_DBOX_1	132:140	Mutation rewiring degron network	0.1389
p.P708H	DO232224	PBCA	ICGC	PGSTS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.1944
p.D141N	ACH-000768	Breast Cancer	CCLE	ARDGLGGLP	DEG_APCC_DBOX_1	132:140	Mutation rewiring degron network	0.3056

Kaplan plot for USP5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

USP5

UniProt ID: P45974

Entrez ID: 8078

Protein name: Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for USP5 in