DegronMD

Uniprot ID: P45974

Source protein: Ubiquitin carboxyl-terminal hydrolase 5

Source gene: USP5

Class: DEG_APCC_DBOX_1

Location: 132:140

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5637

ASA_SCORE: 49.0556

COIL: 0.7431

CONS_SCORE: 0.2992

DSS_SCORE: 0.135

HELIX: 0.1198

FCONS_SCORE: 0.8874

RIG_SCORE: 0.7691

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R146W	TCGA-AA-A022	COAD	TCGA	ARDGLGGLP	DEG_APCC_DBOX_1	0.1667
p.R146W	TCGA-AJ-A5DW	UCEC	TCGA	ARDGLGGLP	DEG_APCC_DBOX_1	0.1667
p.R146W	TCGA-AP-A1DV	UCEC	TCGA	ARDGLGGLP	DEG_APCC_DBOX_1	0.1667
p.R146W	DO10647	COAD	ICGC	ARDGLGGLP	DEG_APCC_DBOX_1	0.1667
p.R146W	DO229221	THCA	ICGC	ARDGLGGLP	DEG_APCC_DBOX_1	0.1667
p.R146W	DO50075	UCEC	ICGC	ARDGLGGLP	DEG_APCC_DBOX_1	0.1667
p.R146W	DO43186	UCEC	ICGC	ARDGLGGLP	DEG_APCC_DBOX_1	0.1667
p.R146W	SIDM00145	T-Lymphoblastic Leukemia	GDSC	ARDGLGGLP	DEG_APCC_DBOX_1	0.1667
p.R146W	ACH-001127	Leukemia	CCLE	ARDGLGGLP	DEG_APCC_DBOX_1	0.1667
p.R146W	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	ARDGLGGLP	DEG_APCC_DBOX_1	0.1667
p.I124M	TCGA-B5-A11N	UCEC	TCGA	ARDGLGGLP	DEG_APCC_DBOX_1	0.1111
p.I124M	DO41458	UCEC	ICGC	ARDGLGGLP	DEG_APCC_DBOX_1	0.1111
p.D134G	DO227996	COCA	ICGC	ARDGLGGLP	DEG_APCC_DBOX_1	0.6087
p.D127Y	DO229018	LICA	ICGC	ARDGLGGLP	DEG_APCC_DBOX_1	0.1944
p.V147L	DO232073	ORCA	ICGC	ARDGLGGLP	DEG_APCC_DBOX_1	0.1389
p.D141N	ACH-000768	Breast Cancer	CCLE	ARDGLGGLP	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P45974	Ubiquitin carboxyl-terminal hydrolase 5	DEG_APCC_DBOX_1	132:140	ARDGLGGLP	APC,CDC20,FZR1	0.5637	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons