DegronMD - O00444(PLK4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F307C	TCGA-28-1760	GBM	TCGA	ASSST	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.1389
p.F307C	DO13725	GBM	ICGC	ASSST	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.1389
p.S303I	TCGA-85-A4CN	LUSC	TCGA	ASSST	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.25
p.S303I	DO45510	LUSC	ICGC	ASSST	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.25
p.A467S	TCGA-91-6836	LUAD	TCGA	PTPQTE	DEG_SCF_FBW7_2	469:474	Mutation rewiring degron network	0.2778
p.A467S	DO23854	LUAD	ICGC	PTPQTE	DEG_SCF_FBW7_2	469:474	Mutation rewiring degron network	0.2778
p.S255I	TCGA-A5-A0G2	UCEC	TCGA	DRLSLSSVL	DEG_APCC_DBOX_1	252:260	Mutation altering degron motif	0.7341
p.S255I	DO41235	UCEC	ICGC	DRLSLSSVL	DEG_APCC_DBOX_1	252:260	Mutation altering degron motif	0.7341
p.F799S	TCGA-A6-6781	COAD	TCGA	PGSTS	DEG_SPOP_SBC_1	807:811	Mutation rewiring degron network	0.1111
p.L246F	TCGA-AA-3693	COAD	TCGA	DRLSLSSVL	DEG_APCC_DBOX_1	252:260	Mutation rewiring degron network	0.1667
p.L246F	DO9330	COAD	ICGC	DRLSLSSVL	DEG_APCC_DBOX_1	252:260	Mutation rewiring degron network	0.1667
p.L246F	DO222662	MELA	ICGC	DRLSLSSVL	DEG_APCC_DBOX_1	252:260	Mutation rewiring degron network	0.1667
p.R310T	TCGA-AC-A23H	BRCA	TCGA	ASSST	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.0556
p.R310T	DO2401	BRCA	ICGC	ASSST	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.0556
p.R310I	TCGA-AX-A0J0	UCEC	TCGA	ASSST	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.0556
p.R310I	DO41133	UCEC	ICGC	ASSST	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.0556
p.P807S	TCGA-AX-A2HC	UCEC	TCGA	PGSTS	DEG_SPOP_SBC_1	807:811	Mutation altering degron motif	0.6752
p.P463L	TCGA-CD-A4MI	STAD	TCGA	PTPQTE	DEG_SCF_FBW7_2	469:474	Mutation rewiring degron network	0.1667
p.P463L	DO47717	STAD	ICGC	PTPQTE	DEG_SCF_FBW7_2	469:474	Mutation rewiring degron network	0.1667
p.G481W	TCGA-D3-A1QA	SKCM	TCGA	PTPQTE	DEG_SCF_FBW7_2	469:474	Mutation rewiring degron network	0.1389
p.G481W	DO47469	SKCM	ICGC	PTPQTE	DEG_SCF_FBW7_2	469:474	Mutation rewiring degron network	0.1389
p.P469Q	TCGA-D3-A2JD	SKCM	TCGA	PTPQTE	DEG_SCF_FBW7_2	469:474	Mutation altering degron motif	0.7035
p.P469Q	TCGA-EE-A3AA	SKCM	TCGA	PTPQTE	DEG_SCF_FBW7_2	469:474	Mutation altering degron motif	0.7035
p.P469Q	DO37543	SKCM	ICGC	PTPQTE	DEG_SCF_FBW7_2	469:474	Mutation altering degron motif	0.7035
p.P469Q	DO37571	SKCM	ICGC	PTPQTE	DEG_SCF_FBW7_2	469:474	Mutation altering degron motif	0.7035
p.F798C	TCGA-D9-A6EC	SKCM	TCGA	PGSTS	DEG_SPOP_SBC_1	807:811	Mutation rewiring degron network	0.0833
p.S301G	TCGA-DI-A1BU	UCEC	TCGA	ASSST	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.3056
p.S301G	DO42023	UCEC	ICGC	ASSST	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.3056
p.S821F	TCGA-DK-AA71	BLCA	TCGA	PGSTS	DEG_SPOP_SBC_1	807:811	Mutation blocking phosphorylation signal	0.5
p.G808D	TCGA-FS-A4F8	SKCM	TCGA	PGSTS	DEG_SPOP_SBC_1	807:811	Mutation altering degron motif	0.6087
p.R267Q	DO228683	EOPC	ICGC	DRLSLSSVL	DEG_APCC_DBOX_1	252:260	Mutation rewiring degron network	0.1389
p.R267Q	DO23468	LINC	ICGC	DRLSLSSVL	DEG_APCC_DBOX_1	252:260	Mutation rewiring degron network	0.1389
p.R267Q	SIDM00216	Colorectal Carcinoma	GDSC	DRLSLSSVL	DEG_APCC_DBOX_1	252:260	Mutation rewiring degron network	0.1389
p.R267Q	SIDM00247	Gastric Carcinoma	GDSC	DRLSLSSVL	DEG_APCC_DBOX_1	252:260	Mutation rewiring degron network	0.1389
p.R267Q	SNU-175	large intestine	COSMIC	DRLSLSSVL	DEG_APCC_DBOX_1	252:260	Mutation rewiring degron network	0.1389
p.R267Q	MKN45	stomach	COSMIC	DRLSLSSVL	DEG_APCC_DBOX_1	252:260	Mutation rewiring degron network	0.1389
p.D308G	DO233197	GACA	ICGC	ASSST	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.1111
p.G819V	DO228456	LICA	ICGC	PGSTS	DEG_SPOP_SBC_1	807:811	Mutation rewiring degron network	0.1111
p.W820L	DO228948	LICA	ICGC	PGSTS	DEG_SPOP_SBC_1	807:811	Mutation rewiring degron network	0.0833
p.W820L	DO218860	SKCA	ICGC	PGSTS	DEG_SPOP_SBC_1	807:811	Mutation rewiring degron network	0.0833
p.L476F	DO229027	LICA	ICGC	PTPQTE	DEG_SCF_FBW7_2	469:474	Mutation rewiring degron network	0.2778
p.D308Y	DO229038	LICA	ICGC	ASSST	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.1111
p.S798I	DO229041	LICA	ICGC	PGSTS	DEG_SPOP_SBC_1	807:811	Mutation rewiring degron network	0.0833
p.A807S	DO229008	LICA	ICGC	PGSTS	DEG_SPOP_SBC_1	807:811	Mutation altering degron motif	0.7588
p.W820C	DO52302	LIHC	ICGC	PGSTS	DEG_SPOP_SBC_1	807:811	Mutation rewiring degron network	0.0833
p.W820C	DO218966	PAAD	ICGC	PGSTS	DEG_SPOP_SBC_1	807:811	Mutation rewiring degron network	0.0833
p.S812T	DO231734	LINC	ICGC	PGSTS	DEG_SPOP_SBC_1	807:811	Mutation rewiring degron network	0.3056
p.L245F	DO229295	LMS	ICGC	DRLSLSSVL	DEG_APCC_DBOX_1	252:260	Mutation rewiring degron network	0.1389
p.S812C	DO25847	LUAD	ICGC	PGSTS	DEG_SPOP_SBC_1	807:811	Mutation rewiring degron network	0.3056
p.R468W	DO220882	MELA	ICGC	PTPQTE	DEG_SCF_FBW7_2	469:474	Mutation rewiring degron network	0.3056
p.A484D	DO232224	PBCA	ICGC	PTPQTE	DEG_SCF_FBW7_2	469:474	Mutation rewiring degron network	0.0556
p.Q471H	DO37407	SKCM	ICGC	PTPQTE	DEG_SCF_FBW7_2	469:474	Mutation altering degron motif	0.7582
p.R468L	DO37901	SKCM	ICGC	PTPQTE	DEG_SCF_FBW7_2	469:474	Mutation rewiring degron network	0.3056
p.Q471R	DO42033	UCEC	ICGC	PTPQTE	DEG_SCF_FBW7_2	469:474	Mutation altering degron motif	0.7329
p.L799I	DO223286	UCEC	ICGC	PGSTS	DEG_SPOP_SBC_1	807:811	Mutation rewiring degron network	0.1111
p.S299R	SIDM02021	Esophageal Carcinoma	GDSC	ASSST	DEG_SPOP_SBC_1	296:300	Mutation altering degron motif	0.7427
p.I801V	SIDM00084	Glioblastoma	GDSC	PGSTS	DEG_SPOP_SBC_1	807:811	Mutation rewiring degron network	0.1667
p.D308N	SIDM00281	Other Solid Cancers	GDSC	ASSST	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.1111
p.D308N	ACH-002100	Skin Cancer	CCLE	ASSST	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.1111
p.D308N	DJM-1	skin	COSMIC	ASSST	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.1111
p.S269Y	SIDM00193	Colorectal Carcinoma	GDSC	DRLSLSSVL	DEG_APCC_DBOX_1	252:260	Mutation rewiring degron network	0.0833
p.S269Y	ACH-000991	Colon/Colorectal Cancer	CCLE	DRLSLSSVL	DEG_APCC_DBOX_1	252:260	Mutation rewiring degron network	0.0833
p.S269Y	SNU-81	large intestine	COSMIC	DRLSLSSVL	DEG_APCC_DBOX_1	252:260	Mutation rewiring degron network	0.0833
p.P819S	SIDM01080	Oral Cavity Carcinoma	GDSC	PGSTS	DEG_SPOP_SBC_1	807:811	Mutation rewiring degron network	0.1111
p.P819S	SCC-9	upper aerodigestive tract	COSMIC	PGSTS	DEG_SPOP_SBC_1	807:811	Mutation rewiring degron network	0.1111
p.L276V	SIDM00118	Colorectal Carcinoma	GDSC	DSGHAT	DEG_SCF_TRCP1_1	284:289	Mutation rewiring degron network	0.1111
p.L276V	ACH-001081	Colon/Colorectal Cancer	CCLE	DSGHAT	DEG_SCF_TRCP1_1	284:289	Mutation rewiring degron network	0.1111
p.L276V	HCC2998	large intestine	COSMIC	DSGHAT	DEG_SCF_TRCP1_1	284:289	Mutation rewiring degron network	0.1111
p.A484V	ACH-000998	Colon/Colorectal Cancer	CCLE	PTPQTE	DEG_SCF_FBW7_2	469:474	Mutation rewiring degron network	0.0556
p.A484V	CW-2	large intestine	COSMIC	PTPQTE	DEG_SCF_FBW7_2	469:474	Mutation rewiring degron network	0.0556
p.T292A	ACH-000999	Colon/Colorectal Cancer	CCLE	DSGHAT	DEG_SCF_TRCP1_1	284:289	Mutation rewiring degron network	0.25
p.T292A	ACH-000999	Colon/Colorectal Cancer	CCLE	ASSST	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.2222
p.F307L	ACH-001814	Bone Cancer	CCLE	ASSST	DEG_SPOP_SBC_1	296:300	Mutation rewiring degron network	0.1389
p.T459A	ACH-001834	Bile Duct Cancer	CCLE	PTPQTE	DEG_SCF_FBW7_2	469:474	Mutation rewiring degron network	0.0556
p.T459A	ACH-001835	Bile Duct Cancer	CCLE	PTPQTE	DEG_SCF_FBW7_2	469:474	Mutation rewiring degron network	0.0556
p.T459A	ACH-001836	Bile Duct Cancer	CCLE	PTPQTE	DEG_SCF_FBW7_2	469:474	Mutation rewiring degron network	0.0556
p.T481R	TUR	haematopoietic and lymphoid tissue	COSMIC	PTPQTE	DEG_SCF_FBW7_2	469:474	Mutation rewiring degron network	0.1389
p.S806T	HCT-116	large intestine	COSMIC	PGSTS	DEG_SPOP_SBC_1	807:811	Mutation rewiring degron network	0.3056
p.D276N	DJM-1	skin	COSMIC	DSGHAT	DEG_SCF_TRCP1_1	284:289	Mutation rewiring degron network	0.1111
p.D267N	DJM-1	skin	COSMIC	DRLSLSSVL	DEG_APCC_DBOX_1	252:260	Mutation rewiring degron network	0.1389
p.A477V	CW-2	large intestine	COSMIC	PTPQTE	DEG_SCF_FBW7_2	469:474	Mutation rewiring degron network	0.25
p.L244V	HCC2998	large intestine	COSMIC	DRLSLSSVL	DEG_APCC_DBOX_1	252:260	Mutation rewiring degron network	0.1111

Kaplan plot for PLK4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLK4

UniProt ID: O00444

Entrez ID: 10733

Protein name: Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase 18) (Serine/threonine-protein kinase Sak)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLK4 in