DegronMD

Uniprot ID: O00444

Source protein: Serine/threonine-protein kinase PLK4

Source gene: PLK4

Class: DEG_APCC_DBOX_1

Location: 252:260

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9765

ASA_SCORE: 47.3556

COIL: 0.404

CONS_SCORE: 0.6416

DSS_SCORE: 0.3505

HELIX: 0.5796

FCONS_SCORE: 1.0421

RIG_SCORE: 0.7192

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S255I	TCGA-A5-A0G2	UCEC	TCGA	DRLSLSSVL	DEG_APCC_DBOX_1	0.7341
p.S255I	DO41235	UCEC	ICGC	DRLSLSSVL	DEG_APCC_DBOX_1	0.7341
p.L246F	TCGA-AA-3693	COAD	TCGA	DRLSLSSVL	DEG_APCC_DBOX_1	0.1667
p.L246F	DO9330	COAD	ICGC	DRLSLSSVL	DEG_APCC_DBOX_1	0.1667
p.L246F	DO222662	MELA	ICGC	DRLSLSSVL	DEG_APCC_DBOX_1	0.1667
p.R267Q	DO228683	EOPC	ICGC	DRLSLSSVL	DEG_APCC_DBOX_1	0.1389
p.R267Q	DO23468	LINC	ICGC	DRLSLSSVL	DEG_APCC_DBOX_1	0.1389
p.R267Q	SIDM00216	Colorectal Carcinoma	GDSC	DRLSLSSVL	DEG_APCC_DBOX_1	0.1389
p.R267Q	SIDM00247	Gastric Carcinoma	GDSC	DRLSLSSVL	DEG_APCC_DBOX_1	0.1389
p.R267Q	SNU-175	large_intestine	COSMIC	DRLSLSSVL	DEG_APCC_DBOX_1	0.1389
p.R267Q	MKN45	stomach	COSMIC	DRLSLSSVL	DEG_APCC_DBOX_1	0.1389
p.L245F	DO229295	LMS	ICGC	DRLSLSSVL	DEG_APCC_DBOX_1	0.1389
p.S269Y	SIDM00193	Colorectal Carcinoma	GDSC	DRLSLSSVL	DEG_APCC_DBOX_1	0.0833
p.S269Y	ACH-000991	Colon/Colorectal Cancer	CCLE	DRLSLSSVL	DEG_APCC_DBOX_1	0.0833
p.S269Y	SNU-81	large_intestine	COSMIC	DRLSLSSVL	DEG_APCC_DBOX_1	0.0833
p.D267N	DJM-1	skin	COSMIC	DRLSLSSVL	DEG_APCC_DBOX_1	0.1389
p.L244V	HCC2998	large_intestine	COSMIC	DRLSLSSVL	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00444	Serine/threonine-protein kinase PLK4	DEG_APCC_DBOX_1	252:260	DRLSLSSVL	APC,CDC20,FZR1	0.9765	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons