DegronMD

Uniprot ID: O00444

Source protein: Serine/threonine-protein kinase PLK4

Source gene: PLK4

Class: DEG_SCF_FBW7_2

Location: 469:474

E3 ligase: FBXW7

DEGRON score: 0.9644

ASA_SCORE: 81.0667

COIL: 0.7923

CONS_SCORE: 0.3292

DSS_SCORE: 0.5583

HELIX: 0.1645

FCONS_SCORE: 0.9275

RIG_SCORE: 0.7133

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A467S	TCGA-91-6836	LUAD	TCGA	PTPQTE	DEG_SCF_FBW7_2	0.2778
p.A467S	DO23854	LUAD	ICGC	PTPQTE	DEG_SCF_FBW7_2	0.2778
p.P463L	TCGA-CD-A4MI	STAD	TCGA	PTPQTE	DEG_SCF_FBW7_2	0.1667
p.P463L	DO47717	STAD	ICGC	PTPQTE	DEG_SCF_FBW7_2	0.1667
p.G481W	TCGA-D3-A1QA	SKCM	TCGA	PTPQTE	DEG_SCF_FBW7_2	0.1389
p.G481W	DO47469	SKCM	ICGC	PTPQTE	DEG_SCF_FBW7_2	0.1389
p.P469Q	TCGA-D3-A2JD	SKCM	TCGA	PTPQTE	DEG_SCF_FBW7_2	0.7035
p.P469Q	TCGA-EE-A3AA	SKCM	TCGA	PTPQTE	DEG_SCF_FBW7_2	0.7035
p.P469Q	DO37543	SKCM	ICGC	PTPQTE	DEG_SCF_FBW7_2	0.7035
p.P469Q	DO37571	SKCM	ICGC	PTPQTE	DEG_SCF_FBW7_2	0.7035
p.L476F	DO229027	LICA	ICGC	PTPQTE	DEG_SCF_FBW7_2	0.2778
p.R468W	DO220882	MELA	ICGC	PTPQTE	DEG_SCF_FBW7_2	0.3056
p.A484D	DO232224	PBCA	ICGC	PTPQTE	DEG_SCF_FBW7_2	0.0556
p.Q471H	DO37407	SKCM	ICGC	PTPQTE	DEG_SCF_FBW7_2	0.7582
p.R468L	DO37901	SKCM	ICGC	PTPQTE	DEG_SCF_FBW7_2	0.3056
p.Q471R	DO42033	UCEC	ICGC	PTPQTE	DEG_SCF_FBW7_2	0.7329
p.A484V	ACH-000998	Colon/Colorectal Cancer	CCLE	PTPQTE	DEG_SCF_FBW7_2	0.0556
p.A484V	CW-2	large_intestine	COSMIC	PTPQTE	DEG_SCF_FBW7_2	0.0556
p.T459A	ACH-001834	Bile Duct Cancer	CCLE	PTPQTE	DEG_SCF_FBW7_2	0.0556
p.T459A	ACH-001835	Bile Duct Cancer	CCLE	PTPQTE	DEG_SCF_FBW7_2	0.0556
p.T459A	ACH-001836	Bile Duct Cancer	CCLE	PTPQTE	DEG_SCF_FBW7_2	0.0556
p.T481R	TUR	haematopoietic_and_lymphoid_tissue	COSMIC	PTPQTE	DEG_SCF_FBW7_2	0.1389
p.A477V	CW-2	large_intestine	COSMIC	PTPQTE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00444	Serine/threonine-protein kinase PLK4	DEG_SCF_FBW7_2	469:474	PTPQTE	FBXW7	0.9644	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons