DegronMD

Uniprot ID: O00444

Source protein: Serine/threonine-protein kinase PLK4

Source gene: PLK4

Class: DEG_SCF_TRCP1_1

Location: 284:289

E3 ligase: BTRC

DEGRON score: 0.9952

ASA_SCORE: 73.8167

COIL: 0.7932

CONS_SCORE: 0.5143

DSS_SCORE: 0.3752

HELIX: 0.097

FCONS_SCORE: 1.3186

RIG_SCORE: 0.7009

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L276V	SIDM00118	Colorectal Carcinoma	GDSC	DSGHAT	DEG_SCF_TRCP1_1	0.1111
p.L276V	ACH-001081	Colon/Colorectal Cancer	CCLE	DSGHAT	DEG_SCF_TRCP1_1	0.1111
p.L276V	HCC2998	large_intestine	COSMIC	DSGHAT	DEG_SCF_TRCP1_1	0.1111
p.T292A	ACH-000999	Colon/Colorectal Cancer	CCLE	DSGHAT	DEG_SCF_TRCP1_1	0.25
p.D276N	DJM-1	skin	COSMIC	DSGHAT	DEG_SCF_TRCP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00444	Serine/threonine-protein kinase PLK4	DEG_SCF_TRCP1_1	284:289	DSGHAT	BTRC	0.9952	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons