DegronMD - Q9H1V8(SLC6A17)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S701L	TCGA-95-7039	LUAD	TCGA	PGSTS	DEG_SPOP_SBC_1	697:701	Mutation altering degron motif	0.7667
p.S701L	TCGA-W3-AA1V	SKCM	TCGA	PGSTS	DEG_SPOP_SBC_1	697:701	Mutation altering degron motif	0.7667
p.S701L	DO23907	LUAD	ICGC	PGSTS	DEG_SPOP_SBC_1	697:701	Mutation altering degron motif	0.7667
p.S701L	DO51276	SKCM	ICGC	PGSTS	DEG_SPOP_SBC_1	697:701	Mutation altering degron motif	0.7667
p.D671N	TCGA-AP-A056	UCEC	TCGA	TRFILSKVP	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.2778
p.D671N	DO43971	UCEC	ICGC	TRFILSKVP	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.2778
p.A684V	TCGA-AX-A0J1	UCEC	TCGA	TRFILSKVP	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.25
p.A684V	DO41199	UCEC	ICGC	TRFILSKVP	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.25
p.R674H	TCGA-CV-A45V	HNSC	TCGA	TRFILSKVP	DEG_APCC_DBOX_1	673:681	Mutation altering degron motif	0.8244
p.R674H	DO52059	HNSC	ICGC	TRFILSKVP	DEG_APCC_DBOX_1	673:681	Mutation altering degron motif	0.8244
p.R674H	SIDM00451	T-Lymphoblastic Leukemia	GDSC	TRFILSKVP	DEG_APCC_DBOX_1	673:681	Mutation altering degron motif	0.8244
p.R674H	ACH-000937	Leukemia	CCLE	TRFILSKVP	DEG_APCC_DBOX_1	673:681	Mutation altering degron motif	0.8244
p.R674H	PF-382	haematopoietic and lymphoid tissue	COSMIC	TRFILSKVP	DEG_APCC_DBOX_1	673:681	Mutation altering degron motif	0.8244
p.R674S	TCGA-D3-A1Q3	SKCM	TCGA	TRFILSKVP	DEG_APCC_DBOX_1	673:681	Mutation altering degron motif	0.7427
p.R674S	DO47509	SKCM	ICGC	TRFILSKVP	DEG_APCC_DBOX_1	673:681	Mutation altering degron motif	0.7427
p.R674C	TCGA-D9-A4Z3	SKCM	TCGA	TRFILSKVP	DEG_APCC_DBOX_1	673:681	Mutation altering degron motif	0.8301
p.R674C	DO47555	SKCM	ICGC	TRFILSKVP	DEG_APCC_DBOX_1	673:681	Mutation altering degron motif	0.8301
p.P685S	TCGA-DD-A1EK	LIHC	TCGA	TRFILSKVP	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.2222
p.P685S	DO48492	LIHC	ICGC	TRFILSKVP	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.2222
p.P685S	SIDM00335	Endometrial Carcinoma	GDSC	TRFILSKVP	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.2222
p.P685S	MFE-280	endometrium	COSMIC	TRFILSKVP	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.2222
p.G707C	TCGA-GN-A262	SKCM	TCGA	PGSTS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.1667
p.G707C	DO37515	SKCM	ICGC	PGSTS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.1667
p.S699I	DO229028	LICA	ICGC	PGSTS	DEG_SPOP_SBC_1	697:701	Mutation altering degron motif	0.7341
p.A684T	DO231186	LUSC	ICGC	TRFILSKVP	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.25
p.P687L	DO222731	MELA	ICGC	TRFILSKVP	DEG_APCC_DBOX_1	673:681	Mutation rewiring degron network	0.1667
p.P687L	DO222731	MELA	ICGC	PGSTS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.0556
p.N710S	SIDM00674	Non-Cancerous	GDSC	PGSTS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.0833
p.N710S	SIDM00675	Breast Carcinoma	GDSC	PGSTS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.0833
p.N710S	ACH-000276	Breast Cancer	CCLE	PGSTS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.0833
p.N710S	ACH-002377	Non-Cancerous	CCLE	PGSTS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.0833
p.S682N	SIDM01088	Endometrial Carcinoma	GDSC	TRFILSKVP	DEG_APCC_DBOX_1	673:681	Mutation blocking phosphorylation signal	0.75
p.S682N	ACH-000965	Endometrial/Uterine Cancer	CCLE	TRFILSKVP	DEG_APCC_DBOX_1	673:681	Mutation blocking phosphorylation signal	0.75
p.S682N	RL95-2	endometrium	COSMIC	TRFILSKVP	DEG_APCC_DBOX_1	673:681	Mutation blocking phosphorylation signal	0.75
p.L695V	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	PGSTS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.2778
p.L695V	ACH-000888	Lung Cancer	CCLE	PGSTS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.2778
p.L695V	NCI-H1793	lung	COSMIC	PGSTS	DEG_SPOP_SBC_1	697:701	Mutation rewiring degron network	0.2778
p.S678N	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	TRFILSKVP	DEG_APCC_DBOX_1	673:681	Mutation altering degron motif	0.5958

Kaplan plot for SLC6A17 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC6A17

UniProt ID: Q9H1V8

Entrez ID: 388662

Protein name: Sodium-dependent neutral amino acid transporter SLC6A17 (Sodium-dependent neurotransmitter transporter NTT4) (Solute carrier family 6 member 17)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLC6A17 in