DegronMD

Uniprot ID: Q9H1V8

Source protein: Sodium-dependent neutral amino acid transporter SLC6A17

Source gene: SLC6A17

Class: DEG_APCC_DBOX_1

Location: 673:681

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.806

ASA_SCORE: 83.6444

COIL: 0.5634

CONS_SCORE: 0.2842

DSS_SCORE: 0.5593

HELIX: 0.4079

FCONS_SCORE: 0.9581

RIG_SCORE: 0.7615

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D671N	TCGA-AP-A056	UCEC	TCGA	TRFILSKVP	DEG_APCC_DBOX_1	0.2778
p.D671N	DO43971	UCEC	ICGC	TRFILSKVP	DEG_APCC_DBOX_1	0.2778
p.A684V	TCGA-AX-A0J1	UCEC	TCGA	TRFILSKVP	DEG_APCC_DBOX_1	0.25
p.A684V	DO41199	UCEC	ICGC	TRFILSKVP	DEG_APCC_DBOX_1	0.25
p.R674H	TCGA-CV-A45V	HNSC	TCGA	TRFILSKVP	DEG_APCC_DBOX_1	0.8244
p.R674H	DO52059	HNSC	ICGC	TRFILSKVP	DEG_APCC_DBOX_1	0.8244
p.R674H	SIDM00451	T-Lymphoblastic Leukemia	GDSC	TRFILSKVP	DEG_APCC_DBOX_1	0.8244
p.R674H	ACH-000937	Leukemia	CCLE	TRFILSKVP	DEG_APCC_DBOX_1	0.8244
p.R674H	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	TRFILSKVP	DEG_APCC_DBOX_1	0.8244
p.R674S	TCGA-D3-A1Q3	SKCM	TCGA	TRFILSKVP	DEG_APCC_DBOX_1	0.7427
p.R674S	DO47509	SKCM	ICGC	TRFILSKVP	DEG_APCC_DBOX_1	0.7427
p.R674C	TCGA-D9-A4Z3	SKCM	TCGA	TRFILSKVP	DEG_APCC_DBOX_1	0.8301
p.R674C	DO47555	SKCM	ICGC	TRFILSKVP	DEG_APCC_DBOX_1	0.8301
p.P685S	TCGA-DD-A1EK	LIHC	TCGA	TRFILSKVP	DEG_APCC_DBOX_1	0.2222
p.P685S	DO48492	LIHC	ICGC	TRFILSKVP	DEG_APCC_DBOX_1	0.2222
p.P685S	SIDM00335	Endometrial Carcinoma	GDSC	TRFILSKVP	DEG_APCC_DBOX_1	0.2222
p.P685S	MFE-280	endometrium	COSMIC	TRFILSKVP	DEG_APCC_DBOX_1	0.2222
p.A684T	DO231186	LUSC	ICGC	TRFILSKVP	DEG_APCC_DBOX_1	0.25
p.P687L	DO222731	MELA	ICGC	TRFILSKVP	DEG_APCC_DBOX_1	0.1667
p.S682N	SIDM01088	Endometrial Carcinoma	GDSC	TRFILSKVP	DEG_APCC_DBOX_1	0.75
p.S682N	ACH-000965	Endometrial/Uterine Cancer	CCLE	TRFILSKVP	DEG_APCC_DBOX_1	0.75
p.S682N	RL95-2	endometrium	COSMIC	TRFILSKVP	DEG_APCC_DBOX_1	0.75
p.S678N	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	TRFILSKVP	DEG_APCC_DBOX_1	0.5958

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H1V8	Sodium-dependent neutral amino acid transporter SLC6A17	DEG_APCC_DBOX_1	673:681	TRFILSKVP	APC,CDC20,FZR1	0.806	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons