DegronMD - Q9NQW1(SEC31B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L936M	TCGA-19-5956	GBM	TCGA	PGSTS	DEG_SPOP_SBC_1	925:929	Mutation rewiring degron network	0.1389
p.L936M	DO13863	GBM	ICGC	PGSTS	DEG_SPOP_SBC_1	925:929	Mutation rewiring degron network	0.1389
p.Q820K	TCGA-53-7626	LUAD	TCGA	SQPSHQVPTP	DEG_COP1_1	819:828	Mutation altering degron motif	0.5833
p.Q820K	DO23774	LUAD	ICGC	SQPSHQVPTP	DEG_COP1_1	819:828	Mutation altering degron motif	0.5833
p.A846T	TCGA-A5-A0G2	UCEC	TCGA	VFTPQSS	DEG_SCF_FBW7_1	834:840	Mutation rewiring degron network	0.1667
p.A846T	DO41235	UCEC	ICGC	VFTPQSS	DEG_SCF_FBW7_1	834:840	Mutation rewiring degron network	0.1667
p.M917V	TCGA-AG-3891	READ	TCGA	PGSTS	DEG_SPOP_SBC_1	925:929	Mutation rewiring degron network	0.1111
p.M917V	DO36388	READ	ICGC	PGSTS	DEG_SPOP_SBC_1	925:929	Mutation rewiring degron network	0.1111
p.E811Q	TCGA-AO-A12D	BRCA	TCGA	SQPSHQVPTP	DEG_COP1_1	819:828	Mutation rewiring degron network	0.1111
p.E811Q	DO4707	BRCA	ICGC	SQPSHQVPTP	DEG_COP1_1	819:828	Mutation rewiring degron network	0.1111
p.G921C	TCGA-AX-A060	UCEC	TCGA	PGSTS	DEG_SPOP_SBC_1	925:929	Mutation rewiring degron network	0.2222
p.G921C	DO228581	GACA	ICGC	PGSTS	DEG_SPOP_SBC_1	925:929	Mutation rewiring degron network	0.2222
p.G921C	DO42576	UCEC	ICGC	PGSTS	DEG_SPOP_SBC_1	925:929	Mutation rewiring degron network	0.2222
p.S822Y	TCGA-AX-A06F	UCEC	TCGA	SQPSHQVPTP	DEG_COP1_1	819:828	Mutation altering degron motif	0.712
p.S822Y	DO41752	UCEC	ICGC	SQPSHQVPTP	DEG_COP1_1	819:828	Mutation altering degron motif	0.712
p.P844S	TCGA-B5-A3FA	UCEC	TCGA	VFTPQSS	DEG_SCF_FBW7_1	834:840	Mutation rewiring degron network	0.2222
p.P844S	DO52402	UCEC	ICGC	VFTPQSS	DEG_SCF_FBW7_1	834:840	Mutation rewiring degron network	0.2222
p.P844S	SIDM00007	Other Solid Cancers	GDSC	VFTPQSS	DEG_SCF_FBW7_1	834:840	Mutation rewiring degron network	0.2222
p.P844S	ACH-001550	Skin Cancer	CCLE	VFTPQSS	DEG_SCF_FBW7_1	834:840	Mutation rewiring degron network	0.2222
p.P844S	MCC13	skin	COSMIC	VFTPQSS	DEG_SCF_FBW7_1	834:840	Mutation rewiring degron network	0.2222
p.E811D	TCGA-B9-4117	KIRP	TCGA	SQPSHQVPTP	DEG_COP1_1	819:828	Mutation rewiring degron network	0.1111
p.E811D	DO20770	KIRP	ICGC	SQPSHQVPTP	DEG_COP1_1	819:828	Mutation rewiring degron network	0.1111
p.P828L	TCGA-BF-AAOX	SKCM	TCGA	SQPSHQVPTP	DEG_COP1_1	819:828	Mutation altering degron motif	0.6471
p.P828L	DO223907	SKCM	ICGC	SQPSHQVPTP	DEG_COP1_1	819:828	Mutation altering degron motif	0.6471
p.P916S	TCGA-D1-A17H	UCEC	TCGA	PGSTS	DEG_SPOP_SBC_1	925:929	Mutation rewiring degron network	0.0833
p.P916S	DO41847	UCEC	ICGC	PGSTS	DEG_SPOP_SBC_1	925:929	Mutation rewiring degron network	0.0833
p.A842V	TCGA-FI-A2D5	UCEC	TCGA	VFTPQSS	DEG_SCF_FBW7_1	834:840	Mutation rewiring degron network	0.2778
p.A842V	DO41331	UCEC	ICGC	VFTPQSS	DEG_SCF_FBW7_1	834:840	Mutation rewiring degron network	0.2778
p.P832T	DO229015	LICA	ICGC	SQPSHQVPTP	DEG_COP1_1	819:828	Mutation rewiring degron network	0.2222
p.P832T	DO229015	LICA	ICGC	VFTPQSS	DEG_SCF_FBW7_1	834:840	Mutation rewiring degron network	0.2778
p.P828Q	DO229037	LICA	ICGC	SQPSHQVPTP	DEG_COP1_1	819:828	Mutation altering degron motif	0.7035
p.P916L	DO220877	MELA	ICGC	PGSTS	DEG_SPOP_SBC_1	925:929	Mutation rewiring degron network	0.0833
p.G921S	DO229253	THCA	ICGC	PGSTS	DEG_SPOP_SBC_1	925:929	Mutation rewiring degron network	0.2222
p.M923L	SIDM00734	Non-Small Cell Lung Carcinoma	GDSC	PGSTS	DEG_SPOP_SBC_1	925:929	Mutation rewiring degron network	0.2778
p.M923L	ACH-000589	Lung Cancer	CCLE	PGSTS	DEG_SPOP_SBC_1	925:929	Mutation rewiring degron network	0.2778
p.M923L	NCI-H1437	lung	COSMIC	PGSTS	DEG_SPOP_SBC_1	925:929	Mutation rewiring degron network	0.2778

Kaplan plot for SEC31B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SEC31B

UniProt ID: Q9NQW1

Entrez ID: 25956

Protein name: Protein transport protein Sec31B (SEC31-like protein 2) (SEC31-related protein B) (SEC31B-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SEC31B in