DegronMD

Uniprot ID: Q9NQW1

Source protein: Protein transport protein Sec31B

Source gene: SEC31B

Class: DEG_SCF_FBW7_1

Location: 834:840

E3 ligase: FBXW7

DEGRON score: 0.9986

ASA_SCORE: 80.3857

COIL: 0.9327

CONS_SCORE: 0.3142

DSS_SCORE: 0.7556

HELIX: 0.0214

FCONS_SCORE: 1.0835

RIG_SCORE: 0.6016

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A846T	TCGA-A5-A0G2	UCEC	TCGA	VFTPQSS	DEG_SCF_FBW7_1	0.1667
p.A846T	DO41235	UCEC	ICGC	VFTPQSS	DEG_SCF_FBW7_1	0.1667
p.P844S	TCGA-B5-A3FA	UCEC	TCGA	VFTPQSS	DEG_SCF_FBW7_1	0.2222
p.P844S	DO52402	UCEC	ICGC	VFTPQSS	DEG_SCF_FBW7_1	0.2222
p.P844S	SIDM00007	Other Solid Cancers	GDSC	VFTPQSS	DEG_SCF_FBW7_1	0.2222
p.P844S	ACH-001550	Skin Cancer	CCLE	VFTPQSS	DEG_SCF_FBW7_1	0.2222
p.P844S	MCC13	skin	COSMIC	VFTPQSS	DEG_SCF_FBW7_1	0.2222
p.A842V	TCGA-FI-A2D5	UCEC	TCGA	VFTPQSS	DEG_SCF_FBW7_1	0.2778
p.A842V	DO41331	UCEC	ICGC	VFTPQSS	DEG_SCF_FBW7_1	0.2778
p.P832T	DO229015	LICA	ICGC	VFTPQSS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQW1	Protein transport protein Sec31B	DEG_SCF_FBW7_1	834:840	VFTPQSS	FBXW7	0.9986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons