DegronMD

Uniprot ID: Q9NQW1

Source protein: Protein transport protein Sec31B

Source gene: SEC31B

Class: DEG_COP1_1

Location: 819:828

E3 ligase: COP1

DEGRON score: 0.9897

ASA_SCORE: 92.41

COIL: 0.9486

CONS_SCORE: 0.2893

DSS_SCORE: 0.7444

HELIX: 0.0128

FCONS_SCORE: 1.0976

RIG_SCORE: 0.5581

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q820K	TCGA-53-7626	LUAD	TCGA	SQPSHQVPTP	DEG_COP1_1	0.5833
p.Q820K	DO23774	LUAD	ICGC	SQPSHQVPTP	DEG_COP1_1	0.5833
p.E811Q	TCGA-AO-A12D	BRCA	TCGA	SQPSHQVPTP	DEG_COP1_1	0.1111
p.E811Q	DO4707	BRCA	ICGC	SQPSHQVPTP	DEG_COP1_1	0.1111
p.S822Y	TCGA-AX-A06F	UCEC	TCGA	SQPSHQVPTP	DEG_COP1_1	0.712
p.S822Y	DO41752	UCEC	ICGC	SQPSHQVPTP	DEG_COP1_1	0.712
p.E811D	TCGA-B9-4117	KIRP	TCGA	SQPSHQVPTP	DEG_COP1_1	0.1111
p.E811D	DO20770	KIRP	ICGC	SQPSHQVPTP	DEG_COP1_1	0.1111
p.P828L	TCGA-BF-AAOX	SKCM	TCGA	SQPSHQVPTP	DEG_COP1_1	0.6471
p.P828L	DO223907	SKCM	ICGC	SQPSHQVPTP	DEG_COP1_1	0.6471
p.P832T	DO229015	LICA	ICGC	SQPSHQVPTP	DEG_COP1_1	0.2222
p.P828Q	DO229037	LICA	ICGC	SQPSHQVPTP	DEG_COP1_1	0.7035

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQW1	Protein transport protein Sec31B	DEG_COP1_1	819:828	SQPSHQVPTP	COP1	0.9897	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons