DegronMD - O43159(RRP8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S35C	TCGA-05-4402	LUAD	TCGA	RRQLLATLR	DEG_APCC_DBOX_1	37:45	Mutation rewiring degron network	0.2778
p.S35C	DO24960	LUAD	ICGC	RRQLLATLR	DEG_APCC_DBOX_1	37:45	Mutation rewiring degron network	0.2778
p.S176F	TCGA-06-5416	GBM	TCGA	PGSTS	DEG_SPOP_SBC_1	172:176	Mutation altering degron motif	0.9093
p.S176F	DO10880	GBM	ICGC	PGSTS	DEG_SPOP_SBC_1	172:176	Mutation altering degron motif	0.9093
p.A42V	TCGA-06-5416	GBM	TCGA	RRQLLATLR	DEG_APCC_DBOX_1	37:45	Mutation altering degron motif	0.5825
p.A42V	DO10880	GBM	ICGC	RRQLLATLR	DEG_APCC_DBOX_1	37:45	Mutation altering degron motif	0.5825
p.A49T	TCGA-19-5956	GBM	TCGA	RRQLLATLR	DEG_APCC_DBOX_1	37:45	Mutation rewiring degron network	0.2222
p.A49T	DO13863	GBM	ICGC	RRQLLATLR	DEG_APCC_DBOX_1	37:45	Mutation rewiring degron network	0.2222
p.P177S	TCGA-21-1070	LUSC	TCGA	PGSTS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.3056
p.P177S	DO27088	LUSC	ICGC	PGSTS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.3056
p.D166N	TCGA-55-7283	LUAD	TCGA	PGSTS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.1667
p.D166N	DO23606	LUAD	ICGC	PGSTS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.1667
p.Q39H	TCGA-63-A5MM	LUSC	TCGA	RRQLLATLR	DEG_APCC_DBOX_1	37:45	Mutation altering degron motif	0.647
p.Q39H	DO219153	LUSC	ICGC	RRQLLATLR	DEG_APCC_DBOX_1	37:45	Mutation altering degron motif	0.647
p.R38H	TCGA-AP-A051	UCEC	TCGA	RRQLLATLR	DEG_APCC_DBOX_1	37:45	Mutation altering degron motif	0.8244
p.R38H	DO42673	UCEC	ICGC	RRQLLATLR	DEG_APCC_DBOX_1	37:45	Mutation altering degron motif	0.8244
p.P180S	TCGA-BR-8360	STAD	TCGA	PGSTS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.2222
p.P180S	DO47745	STAD	ICGC	PGSTS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.2222
p.L47I	TCGA-DF-A2KN	UCEC	TCGA	RRQLLATLR	DEG_APCC_DBOX_1	37:45	Mutation rewiring degron network	0.2778
p.L47I	DO223282	UCEC	ICGC	RRQLLATLR	DEG_APCC_DBOX_1	37:45	Mutation rewiring degron network	0.2778
p.P167T	DO227745	COCA	ICGC	PGSTS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.1944
p.K178N	DO233855	GACA	ICGC	PGSTS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.2778
p.R37S	DO229019	LICA	ICGC	RRQLLATLR	DEG_APCC_DBOX_1	37:45	Mutation altering degron motif	0.6316
p.R185S	DO229029	LICA	ICGC	PGSTS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.0833
p.Q31K	DO229025	LICA	ICGC	RRQLLATLR	DEG_APCC_DBOX_1	37:45	Mutation rewiring degron network	0.1667
p.P177H	DO229027	LICA	ICGC	PGSTS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.3056
p.P35S	DO52231	LIHC	ICGC	RRQLLATLR	DEG_APCC_DBOX_1	37:45	Mutation rewiring degron network	0.2778
p.P35S	DO222731	MELA	ICGC	RRQLLATLR	DEG_APCC_DBOX_1	37:45	Mutation rewiring degron network	0.2778
p.G52E	DO26518	LUSC	ICGC	RRQLLATLR	DEG_APCC_DBOX_1	37:45	Mutation rewiring degron network	0.1389
p.P168L	SIDM01015	Chronic Myelogenous Leukemia	GDSC	PGSTS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.2222
p.P168L	ACH-000326	Leukemia	CCLE	PGSTS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.2222
p.P168L	JURL-MK1	haematopoietic and lymphoid tissue	COSMIC	PGSTS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.2222
p.S174F	SIDM00650	Small Cell Lung Carcinoma	GDSC	PGSTS	DEG_SPOP_SBC_1	172:176	Mutation altering degron motif	0.9093
p.S174F	SIDM01681	Non-Cancerous	GDSC	PGSTS	DEG_SPOP_SBC_1	172:176	Mutation altering degron motif	0.9093
p.A27T	SIDM00783	Colorectal Carcinoma	GDSC	RRQLLATLR	DEG_APCC_DBOX_1	37:45	Mutation rewiring degron network	0.0556
p.A27T	ACH-000971	Colon/Colorectal Cancer	CCLE	RRQLLATLR	DEG_APCC_DBOX_1	37:45	Mutation rewiring degron network	0.0556
p.L50M	ACH-001716	Neuroblastoma	CCLE	RRQLLATLR	DEG_APCC_DBOX_1	37:45	Mutation rewiring degron network	0.1944
p.L50M	GOTO	autonomic ganglia	COSMIC	RRQLLATLR	DEG_APCC_DBOX_1	37:45	Mutation rewiring degron network	0.1944

Kaplan plot for RRP8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RRP8

UniProt ID: O43159

Entrez ID: 23378

Protein name: Ribosomal RNA-processing protein 8 (EC 2.1.1.-) (Cerebral protein 1) (Nucleomethylin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RRP8 in