DegronMD

Uniprot ID: O43159

Source protein: Ribosomal RNA-processing protein 8

Source gene: RRP8

Class: DEG_APCC_DBOX_1

Location: 37:45

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8605

ASA_SCORE: 100.4111

COIL: 0.1606

CONS_SCORE: 0.2989

DSS_SCORE: 0.5252

HELIX: 0.8359

FCONS_SCORE: 1.0181

RIG_SCORE: 0.7767

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S35C	TCGA-05-4402	LUAD	TCGA	RRQLLATLR	DEG_APCC_DBOX_1	0.2778
p.S35C	DO24960	LUAD	ICGC	RRQLLATLR	DEG_APCC_DBOX_1	0.2778
p.A42V	TCGA-06-5416	GBM	TCGA	RRQLLATLR	DEG_APCC_DBOX_1	0.5825
p.A42V	DO10880	GBM	ICGC	RRQLLATLR	DEG_APCC_DBOX_1	0.5825
p.A49T	TCGA-19-5956	GBM	TCGA	RRQLLATLR	DEG_APCC_DBOX_1	0.2222
p.A49T	DO13863	GBM	ICGC	RRQLLATLR	DEG_APCC_DBOX_1	0.2222
p.Q39H	TCGA-63-A5MM	LUSC	TCGA	RRQLLATLR	DEG_APCC_DBOX_1	0.647
p.Q39H	DO219153	LUSC	ICGC	RRQLLATLR	DEG_APCC_DBOX_1	0.647
p.R38H	TCGA-AP-A051	UCEC	TCGA	RRQLLATLR	DEG_APCC_DBOX_1	0.8244
p.R38H	DO42673	UCEC	ICGC	RRQLLATLR	DEG_APCC_DBOX_1	0.8244
p.L47I	TCGA-DF-A2KN	UCEC	TCGA	RRQLLATLR	DEG_APCC_DBOX_1	0.2778
p.L47I	DO223282	UCEC	ICGC	RRQLLATLR	DEG_APCC_DBOX_1	0.2778
p.R37S	DO229019	LICA	ICGC	RRQLLATLR	DEG_APCC_DBOX_1	0.6316
p.Q31K	DO229025	LICA	ICGC	RRQLLATLR	DEG_APCC_DBOX_1	0.1667
p.P35S	DO52231	LIHC	ICGC	RRQLLATLR	DEG_APCC_DBOX_1	0.2778
p.P35S	DO222731	MELA	ICGC	RRQLLATLR	DEG_APCC_DBOX_1	0.2778
p.G52E	DO26518	LUSC	ICGC	RRQLLATLR	DEG_APCC_DBOX_1	0.1389
p.A27T	SIDM00783	Colorectal Carcinoma	GDSC	RRQLLATLR	DEG_APCC_DBOX_1	0.0556
p.A27T	ACH-000971	Colon/Colorectal Cancer	CCLE	RRQLLATLR	DEG_APCC_DBOX_1	0.0556
p.L50M	ACH-001716	Neuroblastoma	CCLE	RRQLLATLR	DEG_APCC_DBOX_1	0.1944
p.L50M	GOTO	autonomic_ganglia	COSMIC	RRQLLATLR	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43159	Ribosomal RNA-processing protein 8	DEG_APCC_DBOX_1	37:45	RRQLLATLR	APC,CDC20,FZR1	0.8605	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons