DegronMD

Uniprot ID: P33076

Source protein: MHC class II transactivator

Source gene: CIITA

Class: LIG_APCC_ABBA_1

Location: 62:67

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7415

ASA_SCORE: 73.35

COIL: 0.6107

CONS_SCORE: 0.4064

DSS_SCORE: 0.5142

HELIX: 0.049

FCONS_SCORE: 0.9441

RIG_SCORE: 0.7942

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E61K	TCGA-AC-A5XS	BRCA	TCGA	IELYSE	LIG_APCC_ABBA_1	0.3056
p.E61K	DO50023	BRCA	ICGC	IELYSE	LIG_APCC_ABBA_1	0.3056
p.E61K	DO51082	PRAD	ICGC	IELYSE	LIG_APCC_ABBA_1	0.3056
p.P68S	TCGA-FR-A44A	SKCM	TCGA	IELYSE	LIG_APCC_ABBA_1	0.3056
p.G58V	TCGA-HE-7130	KIRP	TCGA	IELYSE	LIG_APCC_ABBA_1	0.2222
p.G58V	DO20776	KIRP	ICGC	IELYSE	LIG_APCC_ABBA_1	0.2222
p.D69N	TCGA-KR-A7K7	LIHC	TCGA	IELYSE	LIG_APCC_ABBA_1	0.2778
p.D69N	DO230326	COCA	ICGC	IELYSE	LIG_APCC_ABBA_1	0.2778
p.D69N	DO49698	LIHC	ICGC	IELYSE	LIG_APCC_ABBA_1	0.2778
p.D55N	TCGA-W3-A824	SKCM	TCGA	IELYSE	LIG_APCC_ABBA_1	0.1389
p.D55N	DO51271	SKCM	ICGC	IELYSE	LIG_APCC_ABBA_1	0.1389
p.E67V	TCGA-ZP-A9CZ	LIHC	TCGA	IELYSE	LIG_APCC_ABBA_1	0.7693
p.D76Y	DO229041	LICA	ICGC	IELYSE	LIG_APCC_ABBA_1	0.0833
p.A57T	DO232224	PBCA	ICGC	IELYSE	LIG_APCC_ABBA_1	0.1944
p.D76N	DO229086	UTCA	ICGC	IELYSE	LIG_APCC_ABBA_1	0.0833
p.D55G	SIDM00562	Breast Carcinoma	GDSC	IELYSE	LIG_APCC_ABBA_1	0.1389
p.D55G	MRK-nu-1	breast	COSMIC	IELYSE	LIG_APCC_ABBA_1	0.1389
p.L67P	SIDM01774	Pancreatic Carcinoma	GDSC	IELYSE	LIG_APCC_ABBA_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P33076	MHC class II transactivator	LIG_APCC_ABBA_1	62:67	IELYSE	APC,CDC20,FZR1	0.7415	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons