DegronMD

Uniprot ID: P33076

Source protein: MHC class II transactivator

Source gene: CIITA

Class: DEG_APCC_TPR_1

Location: 1128:1130

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5639

ASA_SCORE: 125.3667

COIL: 0.934

CONS_SCORE: 0.5184

DSS_SCORE: 0.854

HELIX: 0.051

FCONS_SCORE: 0.8652

RIG_SCORE: 0.7511

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1120M	TCGA-AA-3715	COAD	TCGA	SLR	DEG_APCC_TPR_1	0.1111
p.L1120M	DO8018	COAD	ICGC	SLR	DEG_APCC_TPR_1	0.1111
p.R1126W	TCGA-CG-5728	STAD	TCGA	SLR	DEG_APCC_TPR_1	0.2778
p.R1126W	TCGA-VQ-A91D	STAD	TCGA	SLR	DEG_APCC_TPR_1	0.2778
p.R1126W	DO51783	STAD	ICGC	SLR	DEG_APCC_TPR_1	0.2778
p.R1126W	DO38619	STAD	ICGC	SLR	DEG_APCC_TPR_1	0.2778
p.R1126L	DO46591	OV	ICGC	SLR	DEG_APCC_TPR_1	0.2778
p.Q1118R	SIDM00782	Colorectal Carcinoma	GDSC	SLR	DEG_APCC_TPR_1	0.0556
p.Q1118R	T84	large_intestine	COSMIC	SLR	DEG_APCC_TPR_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0JLT2	Mediator of RNA polymerase II transcription subunit 19	DEG_APCC_TPR_1	242:244	SLR	APC,CDC20,FZR1	0.9687	More...
P33076	MHC class II transactivator	DEG_APCC_TPR_1	1128:1130	SLR	APC,CDC20,FZR1	0.5639	More...
Q5TB30	DEP domain-containing protein 1A	DEG_APCC_TPR_1	809:811	SLR	APC,CDC20,FZR1	0.9983	More...
Q9UPV9	Trafficking kinesin-binding protein 1	DEG_APCC_TPR_1	951:953	SLR	APC,CDC20,FZR1	0.6844	More...
Q6P996	Pyridoxal-dependent decarboxylase domain-containing protein 1	DEG_APCC_TPR_1	786:788	SLR	APC,CDC20,FZR1	0.9326	More...
Q9BXG8	Spermatogenic leucine zipper protein 1	DEG_APCC_TPR_1	428:430	SLR	APC,CDC20,FZR1	0.9713	More...
Q9ULS6	Potassium voltage-gated channel subfamily S member 2	DEG_APCC_TPR_1	475:477	SLR	APC,CDC20,FZR1	0.8591	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons