DegronMD

Uniprot ID: Q9ULS6

Source protein: Potassium voltage-gated channel subfamily S member 2

Source gene: KCNS2

Class: DEG_APCC_TPR_1

Location: 475:477

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8591

ASA_SCORE: 131.0333

COIL: 0.925

CONS_SCORE: 0.5722

DSS_SCORE: 0.881

HELIX: 0.0807

FCONS_SCORE: 0.9699

RIG_SCORE: 0.6965

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R477P	TCGA-3N-A9WC	SKCM	TCGA	SLR	DEG_APCC_TPR_1	0.7512
p.R477P	DO51234	SKCM	ICGC	SLR	DEG_APCC_TPR_1	0.7512
p.R477C	TCGA-58-A46L	LUSC	TCGA	SLR	DEG_APCC_TPR_1	0.8301
p.R477C	DO45434	LUSC	ICGC	SLR	DEG_APCC_TPR_1	0.8301
p.S468C	DO233260	GACA	ICGC	SLR	DEG_APCC_TPR_1	0.1389
p.E469K	SIDM00140	Melanoma	GDSC	SLR	DEG_APCC_TPR_1	0.1667
p.E469K	ACH-000968	Skin Cancer	CCLE	SLR	DEG_APCC_TPR_1	0.1667
p.E469K	COLO-792	skin	COSMIC	SLR	DEG_APCC_TPR_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0JLT2	Mediator of RNA polymerase II transcription subunit 19	DEG_APCC_TPR_1	242:244	SLR	APC,CDC20,FZR1	0.9687	More...
P33076	MHC class II transactivator	DEG_APCC_TPR_1	1128:1130	SLR	APC,CDC20,FZR1	0.5639	More...
Q5TB30	DEP domain-containing protein 1A	DEG_APCC_TPR_1	809:811	SLR	APC,CDC20,FZR1	0.9983	More...
Q9UPV9	Trafficking kinesin-binding protein 1	DEG_APCC_TPR_1	951:953	SLR	APC,CDC20,FZR1	0.6844	More...
Q6P996	Pyridoxal-dependent decarboxylase domain-containing protein 1	DEG_APCC_TPR_1	786:788	SLR	APC,CDC20,FZR1	0.9326	More...
Q9BXG8	Spermatogenic leucine zipper protein 1	DEG_APCC_TPR_1	428:430	SLR	APC,CDC20,FZR1	0.9713	More...
Q9ULS6	Potassium voltage-gated channel subfamily S member 2	DEG_APCC_TPR_1	475:477	SLR	APC,CDC20,FZR1	0.8591	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons