DegronMD

Uniprot ID: A0JLT2

Source protein: Mediator of RNA polymerase II transcription subunit 19

Source gene: MED19

Class: DEG_APCC_TPR_1

Location: 242:244

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9687

ASA_SCORE: 132.2

COIL: 0.7937

CONS_SCORE: 0.2394

DSS_SCORE: 0.9874

HELIX: 0.188

FCONS_SCORE: 0.9954

RIG_SCORE: 0.5813

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R244C	DO33084	PACA	ICGC	SLR	DEG_APCC_TPR_1	0.8301

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0JLT2	Mediator of RNA polymerase II transcription subunit 19	DEG_APCC_TPR_1	242:244	SLR	APC,CDC20,FZR1	0.9687	More...
P33076	MHC class II transactivator	DEG_APCC_TPR_1	1128:1130	SLR	APC,CDC20,FZR1	0.5639	More...
Q5TB30	DEP domain-containing protein 1A	DEG_APCC_TPR_1	809:811	SLR	APC,CDC20,FZR1	0.9983	More...
Q9UPV9	Trafficking kinesin-binding protein 1	DEG_APCC_TPR_1	951:953	SLR	APC,CDC20,FZR1	0.6844	More...
Q6P996	Pyridoxal-dependent decarboxylase domain-containing protein 1	DEG_APCC_TPR_1	786:788	SLR	APC,CDC20,FZR1	0.9326	More...
Q9BXG8	Spermatogenic leucine zipper protein 1	DEG_APCC_TPR_1	428:430	SLR	APC,CDC20,FZR1	0.9713	More...
Q9ULS6	Potassium voltage-gated channel subfamily S member 2	DEG_APCC_TPR_1	475:477	SLR	APC,CDC20,FZR1	0.8591	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons